First 3D-printed human corneas can aid transplants
London, May 30: In a first, British scientists have 3D printed human corneas that could cut down shortage of eye donors available for transplant.
In the research, researchers from Britain's Newcastle University, mixed stem cells (human corneal stromal cells) from a healthy donor cornea with alginate and collagen to create a solution that could be printed or a "bio-ink".
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.
"Our unique gel -- a combination of alginate and collagen -- keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer," said lead author Che Connon, a professor at the varisty.
The results published in the journal, Experimental Eye Research, also stated that the stem cells could culture -- or grow.
"...we have a ready to use bio-ink containing stem cells allowing users to start printing tissues without having to worry about growing the cells separately," Connon added.
According to the researchers, there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.
Further, the study also demonstrated that the cornea could also be built to match a patient's unique specifications.
The dimensions of the printed tissue were originally taken from an actual cornea. By scanning a patient's eye, they could use the data to rapidly print a cornea which matched the size and shape, the team explained.
"...what we have shown is that it is feasible to print corneas using coordinates taken from a patient eye and that this approach has potential to combat the world-wide shortage," Connon said.
However, the researchers admitted that further investigations on 3D printed corneas are needed before they could be used in transplants.
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Ex-minister Ramanath Rai hits out at BJP leader Ashoka for ‘irresponsible’ comments on KC Venugopal
Mangaluru: Congress leader and former minister B Ramanath Rai slammed BJP leader R Ashoka for calling AICC General Secretary KC Venugopal an agent of the party high command, and asked if the general secretary and other office-bearers in the BJP were commission agents too.
Rai, who addressed a press meet at the Congress office in the city on Friday, expressed fury over the recent comments of the BJP leader that Chief Minister Siddaramaiah was presenting himself in a shameless manner in public life. Ashoka, who is also Leader of the Opposition (LoP) in the Karnataka Legislative Assembly, had said that the Congress government had ‘broken every previous record on corruption-related controversies’.
“Ashoka has spoken with sheer ignorance and displays his lack of maturity, as he often does while facing the media. KC Venugopal has been working at organization of the party and it is unbecoming of Ashoka to criticize Venugopal as he did,” Rai told reporters.
“Being in a responsible position, how acceptable is it for Ashoka to pass disrespectful, random comments about another leader who also holds a responsible position? If KC Venugopal is indeed an agent of the party high command, what should we consider BJP leaders to be? Are they brokers?” he asked
Commenting on Ashoka’s allegations of corruption in the Congress government in Karnataka, Rai pointed out, “The KSRTC land was sold to private parties when he (Ashoka) was transport minister. We can find several such cases across the state, which need to be probed.”
The former minister, however, refused to comment on the incident that occurred at Mangaluru airport during CM Siddaramaiah’s visit to the city recently.
Former mayors Ashraf and Shashidhar Hegde, Congress activists Vishwas Kumar Das, Subhodaya Alva, Shabeer, Baby Kundar, Padmanabha, Nazeer Bajal and Prem were present.
