First 3D-printed human corneas can aid transplants
London, May 30: In a first, British scientists have 3D printed human corneas that could cut down shortage of eye donors available for transplant.
In the research, researchers from Britain's Newcastle University, mixed stem cells (human corneal stromal cells) from a healthy donor cornea with alginate and collagen to create a solution that could be printed or a "bio-ink".
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.
"Our unique gel -- a combination of alginate and collagen -- keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer," said lead author Che Connon, a professor at the varisty.
The results published in the journal, Experimental Eye Research, also stated that the stem cells could culture -- or grow.
"...we have a ready to use bio-ink containing stem cells allowing users to start printing tissues without having to worry about growing the cells separately," Connon added.
According to the researchers, there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.
Further, the study also demonstrated that the cornea could also be built to match a patient's unique specifications.
The dimensions of the printed tissue were originally taken from an actual cornea. By scanning a patient's eye, they could use the data to rapidly print a cornea which matched the size and shape, the team explained.
"...what we have shown is that it is feasible to print corneas using coordinates taken from a patient eye and that this approach has potential to combat the world-wide shortage," Connon said.
However, the researchers admitted that further investigations on 3D printed corneas are needed before they could be used in transplants.
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'Strong evidence' available against Saif attacker, police tell court while opposing his bail plea
Mumbai, Jul 25 (PTI): Police have opposed the bail plea of the Bangladeshi national arrested for allegedly stabbing Bollywood actor Saif Ali Khan with a knife and injuring him at his home here in January this year, telling a Mumbai court there was "strong evidence" against the accused.
Citing a Forensic Science Laboratory report, police reiterated before the sessions court their earlier claim knife fragments that got lodged near the actor's spine during the attack as well as a part found at the crime spot have matched with the weapon recovered from the accused, Shariful Islam.
These three pieces were part of the same weapon (knife) used to attack the filmstar, the police said in a written response to the accused's plea submitted in the court on Thursday (July 24).
Khan was repeatedly stabbed with a knife by an intruder inside his 12th floor apartment in upscale Bandra on January 16 during a robbery attempt.
The 54-year-old actor underwent surgery at Lilavati Hospital to remove a piece of knife that got lodged near his spine during the attack. He was discharged from the private hospital after five days.
Shariful Islam, a Bangladeshi national, was arrested two days later for allegedly stabbing Khan.
The police, in their response, highlighted that the accused is a Bangladeshi citizen residing illegally in India.
If granted bail, there was a possibility that he may flee India and not appear before the court during the trial. The crime committed by the accused is of a "very serious nature, and strong evidence" is available against him, they argued.
In his bail plea, filed through advocate Vipul Dushing, the accused asserted he was innocent and had no prior criminal record.
Investigation into the case has practically concluded with only the filing of a chargesheet pending, the accused contended while seeking bail.
The alleged attacker has been booked under Bharatiya Nyaya Sanhita (BNS) sections related to house trespass, robbery and dacoity with attempt to cause death or grievous injury.
