First 3D-printed human corneas can aid transplants
London, May 30: In a first, British scientists have 3D printed human corneas that could cut down shortage of eye donors available for transplant.
In the research, researchers from Britain's Newcastle University, mixed stem cells (human corneal stromal cells) from a healthy donor cornea with alginate and collagen to create a solution that could be printed or a "bio-ink".
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.
"Our unique gel -- a combination of alginate and collagen -- keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer," said lead author Che Connon, a professor at the varisty.
The results published in the journal, Experimental Eye Research, also stated that the stem cells could culture -- or grow.
"...we have a ready to use bio-ink containing stem cells allowing users to start printing tissues without having to worry about growing the cells separately," Connon added.
According to the researchers, there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.
Further, the study also demonstrated that the cornea could also be built to match a patient's unique specifications.
The dimensions of the printed tissue were originally taken from an actual cornea. By scanning a patient's eye, they could use the data to rapidly print a cornea which matched the size and shape, the team explained.
"...what we have shown is that it is feasible to print corneas using coordinates taken from a patient eye and that this approach has potential to combat the world-wide shortage," Connon said.
However, the researchers admitted that further investigations on 3D printed corneas are needed before they could be used in transplants.
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Maharashtra government considers tweaks to Ladki Bahin scheme amid fiscal strain: Reports
Mumbai: A day after the Mahayuti coalition secured a landslide victory in the Maharashtra Assembly elections, attention has turned to the Ladki Bahin Yojana, a flagship welfare scheme that played a pivotal role in attracting women voters.
The scheme, launched in July 2024, offers ₹1,500 per month to economically disadvantaged women aged 18 to 65. The Mahayuti, in its election manifesto, pledged to increase the amount to ₹2,100 per month, a promise now under scrutiny due to fiscal concerns. With the scheme projected to cost the exchequer ₹33,300 crore from July 2024 to March 2025, bureaucrats are exploring ways to revise its provisions to prevent a financial imbalance.
Finance Minister and NCP leader Ajit Pawar hinted at the challenges, stressing the need for "financial discipline." A senior bureaucrat confirmed that plans are underway to prune the list of beneficiaries, citing the inclusion of ineligible individuals due to incomplete Aadhaar seeding and lack of required ration cards. According to the finance department, nearly one crore women out of the 2.43 crore registered beneficiaries may not qualify for the scheme.
The state’s debt burden is already projected to reach ₹7.82 lakh crore for the fiscal year 2024-25. Officials warn that continuing the scheme in its current form could impact the government’s ability to pay salaries by January. Despite these concerns, the ruling coalition is hesitant to reduce the beneficiary list, likely due to the upcoming civic elections.
Chief Secretary Sujata Saunik is expected to present renegotiation proposals to the new chief minister soon. Meanwhile, Shiv Sena spokesperson Krishna Hegde credited the scheme for increasing the number of women voters and boosting the coalition’s vote share. NCP (SP) leader Sharad Pawar also acknowledged the scheme’s role in mobilising women voters.
Other welfare measures introduced by the government include an electricity bill waiver for farmers and three free LPG cylinders annually for six million households. However, the financial viability of such initiatives remains a pressing concern.
