Ketamine can cut depression, suicidality rapidly: Study
New York, April 16: Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.
The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.
Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.
The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.
For the study, a small group of participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.
However, at 25 days, the effects had levelled out.
While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.
They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse."
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ED attaches fresh assets in PMLA case against Reliance Group; total attachment over Rs 10K cr
New Delhi (PTI): The Enforcement Directorate has attached fresh assets worth Rs 1,120 crore as part of its money laundering probe against the companies of Reliance Group chairman Anil Ambani, officials said.
Eighteen properties, including the Reliance Centre in Mumbai's Ballard Estate, fixed deposits, bank balance and shareholding in unqouted investments of Reliance Anil Ambani Group have been provisionally attached under the Prevention of Money Laundering Act (PMLA), they said.
Another set of seven properties of Reliance Infrastructure Ltd, two properties of Reliance Power Ltd, nine properties of Reliance Value Service Private Ltd, fixed deposits in the name of Reliance Value Service Private Ltd, Reliance Venture Asset Management Private Lt, Phi Management Solutions Private Ltd, Adhar Property Consultancy Pvt Ltd, Gamesa Investment Management Private Ltd and investments made in unquoted investment by Reliance Venture Asset Management Private Ltd and Phi Management Solutions Private Ltd have also been attached, they said.
The ED had earlier attached properties worth over Rs 8,997 crore in the bank fraud cases related to Reliance Communications Ltd (RCOM), Reliance Commercial Finance Ltd, and Reliance Home Finance Ltd.
The total attachment in the case against the Reliance Group is now Rs 10,117 crore.
