Ketamine can cut depression, suicidality rapidly: Study
New York, April 16: Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.
The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.
Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.
The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.
For the study, a small group of participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.
However, at 25 days, the effects had levelled out.
While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.
They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse."
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Lt Gen NS Raja Subramani to be India's next Chief of Defence Staff
New Delhi (PTI): Lt Gen NS Raja Subramani will be India's new Chief of Defence Staff (CDS) and his key task is set to be to implement the ambitious theaterisation plan that seeks to ensure tri-services synergy.
He will succeed Gen Anil Chauhan whose tenure will come to an end on May 30.
Gen Chauhan, a former Eastern Army Commander, took charge as the country's senior-most military commander in September 2022, over nine months after the first CDS, General Bipin Rawat, died in a helicopter crash in Tamil Nadu.
The government has appointed Lt Gen NS Raja Subramani (Retd) as the Chief of Defence Staff, who will also function as the secretary of the Department of Military Affairs, the defence ministry said on Saturday.
Lt Gen Subramani is currently serving as the military adviser to the National Security Council Secretariat.
Prior to that, he was the Vice Chief of the Army Staff from July 1, 2024 to July 31, 2025, and was General Officer Commanding-in-Chief of the Central Command from March 2023 till June 2024.
As Chief of Defence Staff, Lt Gen Subramani's primary task will be to implement the theaterisation model to bring in tri-services synergy by rolling out integrated military commands.
The officer is a graduate of the National Defence Academy and the Indian Military Academy. He was commissioned into the eighth battalion of the Garhwal Rifles on December 14, 1985.
Lt Gen Subramani is an alumnus of Joint Services Command Staff College, Bracknell (UK), and the National Defence College, New Delhi. He holds a Master of Arts degree from King's College London and an MPhil in defence studies from Madras University.
In his illustrious career spanning over 40 years, Lt Gen Subramani has served across a wide spectrum of conflict and terrain profiles and tenanted a host of Command, Staff and Instructional appointments.
He commanded the 16 Garhwal Rifles in Counter-Insurgency operations in Assam as part of Operation Rhino, the 168 Infantry Brigade in Jammu and Kashmir, and the 17 Mountain Division in the Central Sector, all during a challenging operational environment.
He also has the distinction of commanding two Corps, including the Indian Army's premier strike Corps on the Western Front.
