Ketamine can cut depression, suicidality rapidly: Study
New York, April 16: Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.
The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.
Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.
The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.
For the study, a small group of participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.
However, at 25 days, the effects had levelled out.
While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.
They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse."
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Petrol pump worker killed as SUV hits motorcycle head-on in Gurugram
Gurugram (PTI): A petrol pump worker died after an SUV rammed into his motorcycle in the Sushant Lok area here, police said on Thursday.
The accused driver fled the scene, leaving the vehicle after the accident. An FIR has been registered at the Sushant Lok police station, they said.
According to police, the accident occurred on Wednesday afternoon when Mukesh was travelling from Sector 44 to Sushant Lok on Vyapar Kendra Road for some work.
Near Vyapar Kendra, a white Thar coming from the wrong side at high speed hit his motorcycle head-on, leaving him critically injured, they said.
The driver fled the scene, leaving the vehicle behind, police added.
Eyewitnesses claimed the vehicle had no number plates either at the front or rear.
Locals took Mukesh to a private hospital, where he died during treatment, police said. He was a resident of Rohta Patti in Palwal and worked at a petrol pump in Sector 44.
An FIR was registered against the unidentified driver, based on a complaint lodged by his brother Ashok. The body was handed over to the family after a post-mortem on Thursday, police said.
“The Thar vehicle has been seized from the spot. CCTV footage from the area is being examined, and the driver will be arrested soon,” a Gurugram police spokesperson said.
