Ketamine can cut depression, suicidality rapidly: Study
New York, April 16: Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.
The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.
Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.
The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.
For the study, a small group of participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.
However, at 25 days, the effects had levelled out.
While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.
They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse."
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Elephant attacks man riding his children to school in Belthangady
Belthangady: In a shocking incident, a wild elephant attacked a man and his two children while they were on their way to school on a bike in Shishila village on Wednesday morning. The attack left the trio injured and their bike completely destroyed.
The victim, Vasantha Gowda, a resident of Kallaje in Shishila, was riding his bike to drop his children, Lavya and Advith, at Perla School in Shibaje village. The incident occurred around 8:30 AM when a lone elephant suddenly emerged on a curve in the road.
Startled by the sudden appearance of the animal, Vasantha Gowda braked abruptly, causing the bike to topple. All three fell to the ground, sustaining injuries to their arms and legs. As the elephant advanced, they managed to escape the scene, leaving their bike behind.
The elephant then approached the fallen bike, smashed it with its trunk, and completely crushed it underfoot.
The attack has heightened concerns among residents of Belthangady taluk, where incidents of human-elephant conflict have been rising. Locals have called on the Forest Department to take measures to prevent such encounters and ensure the safety of residents.
