London, April 18: In a breakthrough, scientists have found an antibody, a monthly dose of which could halve the number of debilitating attacks of migraine on patients who have exhausted all other treatments.
The findings showed that people treated with erenumab were nearly three times more likely to have reduced their migraine days by 50 per cent or more than those treated with placebo.
Those treated with erenumab also had a greater average reduction in the number of days they had headaches and the number of days they needed to take drugs to stop the migraines.
"Our study found that erenumab reduced the average number of monthly migraine headaches by more than 50 percent for nearly a third of study participants. That reduction in migraine headache frequency can greatly improve a person's quality of life," said Uwe Reuter from The Charite - University Medicine Berlin in Germany.
Erenumab is a monoclonal antibody that blocks pain signals by targeting a receptor for calcitonin gene-related peptide (CGRP).
This peptide transmits migraine pain signals. Erenumab occupies the nerves to which CGRP would usually bind.
"Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief," Reuter added.
The preliminary results will be presented at the forthcoming American Academy of Neurology's 70th Annual Meeting in Los Angeles.
For the study, 246 people who had episodic migraine were given injections of either 140 milligrams of erenumab or a placebo once a month for three months.
Of the participants, 39 per cent had been treated unsuccessfully with two other medications, 38 per cent with three medications and 23 per cent with four medications.
A total of 30 per cent of the people treated with erenumab had half the number of headaches compared to 14 per cent on placebo.
For those on erenumab, there was an average 1.6 times greater reduction in migraine days and a 1.7 times greater reduction in acute medication days compared to those on placebo.
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Ex-Army officer assaulted, robbed at gunpoint by woman he met through matrimonial website
Mathura(UP), Apr 5 (PTI): A retired Army colonel from Haryana has filed a police complaint here, alleging that he was held hostage, assaulted, looted and forced to participate in an "obscene video" at gunpoint with a woman he met through a matrimonial website, police said on Saturday.
The woman from Mathura, who was allegedly in on the plan to rob him, was working with other accomplices, the ex-armyman said in his complaint filed on Thursday.
According to Barsana Station House Officer (SHO) Raj Kamal Singh, Colonel Rajneesh Soni (retired), a resident of Gurugram, reported that he was contacted by a woman from Barsana on a matrimonial website in January. The woman allegedly agreed to marry him, and they began communicating.
The woman allegedly persuaded the colonel to visit Barsana on January 25, requesting that he visit the Radharani temple. When he arrived, she arranged for his stay at a guest house and took him on a tour of the area, including a visit to the temple, the complainant said.
After returning to the guest house, the woman and her accomplices allegedly told the colonel that her brother had been involved in an accident and they needed to leave immediately. They then led him to a waiting car.
"Once outside the town limits, the colonel alleges that he was attacked by the occupants of the car. They seized his phone, physically assaulted him, and forced him to contact relatives and friends to transfer money," the SHO said.
"He was then taken back to the guest house, where he was allegedly forced to participate in obscene videos and photographs at gunpoint. He was threatened that the videos would be made public if he reported the incident," the officer said.
The colonel has alleged that his purse, bag, gold chain, debit card and Rs. 12,000 in cash were stolen from the guest house.
After an unsuccessful attempt at locating the perpetrators himself, the colonel finally reported the incident to the Barsana police two days ago, he said.
"A case has been registered under relevant sections of the BNS and all facts are being investigated. Further action will be taken as per facts found in the investigation," the SHO said.
