London, April 18: In a breakthrough, scientists have found an antibody, a monthly dose of which could halve the number of debilitating attacks of migraine on patients who have exhausted all other treatments.
The findings showed that people treated with erenumab were nearly three times more likely to have reduced their migraine days by 50 per cent or more than those treated with placebo.
Those treated with erenumab also had a greater average reduction in the number of days they had headaches and the number of days they needed to take drugs to stop the migraines.
"Our study found that erenumab reduced the average number of monthly migraine headaches by more than 50 percent for nearly a third of study participants. That reduction in migraine headache frequency can greatly improve a person's quality of life," said Uwe Reuter from The Charite - University Medicine Berlin in Germany.
Erenumab is a monoclonal antibody that blocks pain signals by targeting a receptor for calcitonin gene-related peptide (CGRP).
This peptide transmits migraine pain signals. Erenumab occupies the nerves to which CGRP would usually bind.
"Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief," Reuter added.
The preliminary results will be presented at the forthcoming American Academy of Neurology's 70th Annual Meeting in Los Angeles.
For the study, 246 people who had episodic migraine were given injections of either 140 milligrams of erenumab or a placebo once a month for three months.
Of the participants, 39 per cent had been treated unsuccessfully with two other medications, 38 per cent with three medications and 23 per cent with four medications.
A total of 30 per cent of the people treated with erenumab had half the number of headaches compared to 14 per cent on placebo.
For those on erenumab, there was an average 1.6 times greater reduction in migraine days and a 1.7 times greater reduction in acute medication days compared to those on placebo.
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Lt Gen NS Raja Subramani to be India's next Chief of Defence Staff
New Delhi (PTI): Lt Gen NS Raja Subramani will be India's new Chief of Defence Staff (CDS) and his key task is set to be to implement the ambitious theaterisation plan that seeks to ensure tri-services synergy.
He will succeed Gen Anil Chauhan whose tenure will come to an end on May 30.
Gen Chauhan, a former Eastern Army Commander, took charge as the country's senior-most military commander in September 2022, over nine months after the first CDS, General Bipin Rawat, died in a helicopter crash in Tamil Nadu.
The government has appointed Lt Gen NS Raja Subramani (Retd) as the Chief of Defence Staff, who will also function as the secretary of the Department of Military Affairs, the defence ministry said on Saturday.
Lt Gen Subramani is currently serving as the military adviser to the National Security Council Secretariat.
Prior to that, he was the Vice Chief of the Army Staff from July 1, 2024 to July 31, 2025, and was General Officer Commanding-in-Chief of the Central Command from March 2023 till June 2024.
As Chief of Defence Staff, Lt Gen Subramani's primary task will be to implement the theaterisation model to bring in tri-services synergy by rolling out integrated military commands.
The officer is a graduate of the National Defence Academy and the Indian Military Academy. He was commissioned into the eighth battalion of the Garhwal Rifles on December 14, 1985.
Lt Gen Subramani is an alumnus of Joint Services Command Staff College, Bracknell (UK), and the National Defence College, New Delhi. He holds a Master of Arts degree from King's College London and an MPhil in defence studies from Madras University.
In his illustrious career spanning over 40 years, Lt Gen Subramani has served across a wide spectrum of conflict and terrain profiles and tenanted a host of Command, Staff and Instructional appointments.
He commanded the 16 Garhwal Rifles in Counter-Insurgency operations in Assam as part of Operation Rhino, the 168 Infantry Brigade in Jammu and Kashmir, and the 17 Mountain Division in the Central Sector, all during a challenging operational environment.
He also has the distinction of commanding two Corps, including the Indian Army's premier strike Corps on the Western Front.
