Researchers suggest Vitamin D therapy can tackle diabetes, cancer
New York, May 13: Enhanced activation of Vitamin D by protecting beta cells may be a potential new approach for treating diabetes as well as other diseases, including cancer, researchers have suggested.
When beta cells -- the cells in the pancreas that produce, store and release the hormone insulin -- become dysfunctional, the body cannot make insulin to control blood sugar (glucose) and levels of glucose can rise to dangerous and even fatal levels.
The researchers found that Vitamin D in cells and mouse models can be beneficial in treating these damaged beta cells.
They also provided new insights about gene regulation that could be applied to developing treatments for other diseases, including cancer.
"We know that diabetes is a disease caused by inflammation. We identified the Vitamin D receptor as an important modulator of both inflammation and beta cell survival," said Ronald Evans, from Salk Institute for Biological Studies in California, US.
Using beta cells created from embryonic stem cells, the team was able to identify a compound -- iBRD9 -- that appeared to enhance the activation of the Vitamin D receptor when it was combined with Vitamin D to improve the survival of beta cells.
In the paper, published in the journal Cell, the team conducted a screening test to look for compounds that improved the survival of beta cells in a dish. They then tested the combination in a mouse model of diabetes and showed that it could bring glucose back to normal levels in the animals.
Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.
"Activating the vitamin D receptor can trigger the anti-inflammatory function of genes to help cells survive under stressed conditions," explained Michael Downes, from the institute.
The researchers noted that although the new compound did not appear to cause any side effects in the mice, further testing is needed before clinical trials can begin.
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Siddaramaiah defends BPL ration card cancellation, says only ineligible beneficiaries affected
New Delhi, Nov 21: In a strong defence of the Karnataka government's move to cancel ration cards, Chief Minister Siddaramaiah on Thursday clarified that only government employees and income tax payers are being weeded out from the Below Poverty Line (BPL) list, not eligible poor beneficiaries.
Talking to reporters, Siddaramaiah asserted that the cancellation is in line with the National Food Security Act, which explicitly bars government employees and income tax payers from receiving BPL ration cards.
He accused the Bharatiya Janata Party (BJP) of raising a politically motivated issue despite originally opposing the food security legislation.
"The rights of eligible ration card holders will be fully protected," the chief minister emphasised, dismissing opposition claims that the move was linked to fund constraints for implementing poll promises.
ALSO READ: Karnataka to reissue BPL cards for eligible families: Deputy CM DK Shivakumar
The controversy stems from the Karnataka government's recent survey identifying 22.63 lakh BPL card-holders as ineligible. This move has triggered a political slugfest between the ruling Congress and the BJP.
Union Food Minister Pralhad Joshi claimed the central government had directed the state to clean the beneficiary lists. He alleged that the card cancellation was a strategy to avoid implementing the state's Gruha Lakshmi Yojana scheme.
Siddaramaiah hit back, reminding that the food security law was introduced during the Manmohan Singh government in 2013 to protect poor citizens' interests. He criticised the BJP for previously reducing food grain allocation from seven kg to five kg per beneficiary during B S Yediyurappa's tenure.
The chief minister categorically stated that there would be no compromise on the five poll guarantees and that sufficient funds were available for their implementation.
Siddaramaiah was in the national capital for the launch of Karnataka Cooperative Milk Producers' Federation Ltd's Nandini brands in Delhi. He also met Union Finance Minister Nirmala Sitharaman on the issue of farm loan.
