Visakhapatnam, Oct 6: Mohammad Shami and Ravindra Jadeja ran through the South African batting in the morning session to put India on the cusp of a big win on day five of the first Test here on Sunday.

Chasing an improbable 395-run target, South Africa were expected to put up a fight like they did in the first innings but Shami's three-wicket burst and Jadeja's probing spell has made it all but certain that India will reach finishing line much faster than what was expected before start of play.

South Africa, resuming the day at 11 for one in nine overs, were 117 for 8 at lunch with Senuran Muthusamy (19 not out off 47) and Dane Piedt (32 not out off 56) delaying the inevitable.

The morning session was extended by 15 minutes for India to complete the formalities but Piedt and Muthusamy frustrated them.

The pitch, which had played fairly for the first four days with the odd ball surprising the batsman, turned tricky on day five. The spinners got the ball to turn sharply and the variable bounce also helped the pacers, as predicted by Cheteshwar Pujara on Saturday.

The collapse began in the second over of the day when Ravichandran Ashwin castled Theunis de Bruyn (10) with one that turned back sharply from wide outside of the off-stump for his record equalling 350th wicket.

With that dismissal, the 33-year-old became the joint fastest to 350 wickets, matching Sri Lanka legend Muttiah Muralitharan's feat in his 66th Test.

After Ashwin provided the early breakthrough, Shami castled Temba Bavuma (0), Faf du Plessis (13) and first innings centurion Quinton de Kock (0) in two short bursts to break the backbone of South African batting.

Bavuma stayed back to ball that jagged back in at low bounce while du Plessis offered a leave to another one which seamed back in, only to see his stumps rattled.

Shami got rid of de Kock with an inswinger, leaving the visitors reeling at 60 for five. It became 70 for six when innings top-scorer and opener Aiden Markram did not get the required elevation and hit it back to Ravindra Jadeja, who took a brilliant one-handed reflex catch.

Jadeja was all over with South African tail, trapping Vernon Philander and Keshav Maharaj in front of the stumps off successive balls to make it 70 for eight in the 27th over.

Piedt and Senuran delayed the inevitable by going for their strokes. Piedt's slog sweep over deep mid-wicket went the distance for the 37th six of the game, breaking the record for most number of maximums in a Test match.

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Bhubaneswar/Cuttack (Odisha) (PTI): The toll in the devastating fire at government-run SCB Medical College and Hospital here climbed to 12 after two more patients succumbed to their burn injuries on Tuesday.

Health and Family Welfare Minister Mukesh Mahaling informed the assembly that a total of 12 people died in the fire incident that took place at the trauma care ICU of the hospital early on Monday.

Terming it a "very sad accident", the minister said, "As soon as the fire broke out, the hospital staffers worked on a war footing to immediately shift 23 patients from the first floor ICU and adjacent wards of the trauma care centre. All of them were shifted to other ICUs and wards."

Seven patients of the trauma care centre died due to their critical condition while five other critically ill patients died while undergoing treatment in other wards and ICUs.

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Eleven medical staffers engaged in the rescue of the patients were also injured in the fire. The injured staff members are undergoing treatment and their lives are out of danger, he said.

Chief Minister Mohan Charan Majhi and Leader of the Opposition in the state assembly, Naveen Patnaik, visited the hospital on Monday. Prime Minister Narendra Modi had also taken stock of the situation.

The state government has constituted a judicial panel to probe the incident, and also formed a fact-finding team headed by Development Commissioner D K Singh that visited the hospital. The team will submit a report to the chief secretary.

The blaze had erupted around 2.48 am on the first floor and is suspected to have been triggered by an electrical short circuit.

SCB Medical College and Hospital is the state's premier health facility, with nearly 2,700 beds and it serves thousands daily.