The English opener led the show with a 29-ball 56 as Kolkata Knight Riders batters fired in unison to notch up a fighting 200/5 after RCB captain Virat Kohli opted to bowl at their home den.
But the spin duo of Varun Chakravarthy (3/24) and rookie Suyash Sharma (2/30) created a top-order mayhem, before Andre Russell (2/29) broke Kohli's resistance to restrict RCB to 179 for eight.
Leading the side in absence of Faf Du Plessis, Kohli struck a 34-ball 54 and kept their hopes up in the 201-run chase after du Plessis (17) Glenn Maxwell (5) fell cheaply.
But all hell broke loose when Venkatesh Iyer took a game game-changing catch at deep midwicket boundary to dismiss Kohli, off Russell.
He dived to his left and rolled over but held the ball firmly as Kohli walked back in disbelief.
With 86 needed from 48 balls, it was left for Dinesh Karthik (22) to keep up their chase but Chakravarthy had the last laugh when he had the veteran RCB keeper-batter en route to his three-for, and it seemed all over for RCB.
KKR thus did a double on RCB, having beaten them in their season-opener by 81 runs.
The loss again proved RCB's over-reliance on their Big Three -- Kohli, Du Plessis and Maxwell.
Cruising at 30 for loss, RCB's flying start was halted by the spin duo of Sharma and Chakravarthy who gave KKR a perfect start, sharing three wickets in between them inside the powerplay (58/3).
RCB's regular skipper Fa du Plessis, who sat out only to be subbed as an Impact Player, looked at his ominous best when he smashed Umesh Yadav on both the sides of the wicket.
Kohli too was looking in full flow as the RCB opening duo feasted on the KKR pacers to start with.
With their trump card spinner Sunil Narine going wicketless in four matches, Rana banked fell back on their latest spin package Suyash Sharma.
It was a move that did the trick as the leggie grabbed the prized scalp of du Plessis with a wrong one and in his next over he trapped Shahbaz Ahmed (2).
Maxwell then got out to Chakravarthy for a second time in as many matches this season which left the RCB's top-order in a disarray.
But there was no letting up from RCB as Mahipal Lomror showed his intent, giving Kohli a perfect support as the duo went about their way.
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Thane (PTI): Three persons were killed and 15 others injured when an auto-rickshaw hit a bus and some other vehicles on a highway in Maharashtra's Thane district on Wednesday morning, police said.
The accident took place at 4.15 am on Mumbai-Agra highway near Khinavli bridge at Ghoteghar village in Shahapur taluka, they said.
The auto-rickshaw driver lost control over the wheels. As a result, the vehicle hit the road-divider, jumped the lane and collided with a private luxury bus, two cars and a tempo coming from the opposite direction, an official from Shahapur police station told PTI.
Three occupants of the bus died on the spot and 15 other persons, including the auto-rickshaw driver, were injured, he said.
The bus was on way from Nashik to Mumbai, the official said.
After being alerted, local police along with the emergency response teams rushed to the spot.
The injured persons were admitted to Shahapur sub-hospital and three of them were reported to be in a serious condition, the official said.
The bodies were sent to a government hospital for post-mortem, the police added.