Highly effective coronavirus antibodies identified, may lead to passive COVID-19 vaccine
Berlin: Scientists have identified highly effective antibodies against the novel coronavirus, which they say can lead to the development of a passive vaccination for COVID-19.
Unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time.
However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, the researchers said.
The research, published in the journal Cell, also shows that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially trigger undesired side effects.
The scientists at the German Center for Neurodegenerative Diseases (DZNE) and Charite - Universitatsmedizin Berlin isolated almost 600 different antibodies from the blood of individuals who had overcome COVID-19, the disease triggered by SARS-CoV-2.
By means of laboratory tests, they were able to narrow this number down to a few antibodies that were particularly effective at binding to the virus.
The researchers then produced these antibodies artificially using cell cultures.
The so-called neutralising antibodies bind to the virus, as crystallographic analysis reveals, and thus prevent the pathogen from entering cells and reproducing, they said.
In addition, virus recognition by antibodies helps immune cells to eliminate the pathogen. Studies in hamsters -- which, like humans, are susceptible to infection by SARS-CoV-2 -- confirmed the high efficacy of the selected antibodies.
If the antibodies were given after an infection, the hamsters developed mild disease symptoms at most. If the antibodies were applied preventively -- before infection -- the animals did not get sick, said Jakob Kreye, coordinator of the research project.
The researchers noted that treating infectious diseases with antibodies has a long history.
For COVID-19, this approach is also being investigated through the administration of plasma derived from the blood of recovered patients. With the plasma, antibodies of donors are transferred, they said.
"Ideally, the most effective antibody is produced in a controlled manner on an industrial scale and in constant quality. This is the goal we are pursuing," said Momsen Reincke, first author of the research.
Three of our antibodies are particularly promising for clinical development, explained Harald Pruss, a research group leader at the DZNE and also a senior physician at Charite Universitatsmedizin Berlin.
"Using these antibodies, we have started to develop a passive vaccination against SARS-CoV-2," Pruss said.
In addition to the treatment of patients, preventive protection of healthy individuals who have had contact with infected persons is also a potential application, the researchers said.
How long the protection lasts will have to be investigated in clinical studies, they said.
This is because, unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time, Pruss said. In general, the protection provided by a passive vaccination is less persistent than that provided by an active vaccination, the researchers said.
However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, they said.
It would be best if both options were available so that a flexible response could be made depending on the situation, Pruss added.
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Stoinis hundred trumps Gaikwad's ton, helps LSG beat hand CSK by six wickets
Chennai, Apr 23: Marcus Stoinis smashed an outstanding century to trump Ruturaj Gaikwad's effort as Lucknow Super Giants beat Chennai Super Kings by six wickets in an IPL match on Tuesday.
Stoinis remained unbeaten 124 off 63 balls with 13 fours and six sixes as LSG completed a record run chase at the Chepauk in 19.3 overs. This was also highest individual score in IPL in a run-chase.
Earlier, skipper Gaikwad led from the front with a superb 60-ball unbeaten 108 as Chennai Super Kings posted a challenging 210 for 4 . Gaikwad's knock, his second IPL hundred, was studded with 12 fours and three sixes. Shivam Dube muscled his way to a 27-ball-66, hitting seven sixes. For LSG, Matt Henry took for 1 for 28.
Brief Scores:
CSK 210 for 4 in 20 overs (Ruturaj Gaikwad 108 not out, Shivam Dube 66, Matt Henry 1/28)
LSG 213/4 (Marcus Stoinis 124 not out).
