Trio win Nobel Medicine Prize for work on cells, oxygen
Stockholm: US researchers William Kaelin and Gregg Semenza and Britain's Peter Ratcliffe on Monday shared the Nobel Medicine Prize for discoveries on how cells sense and adapt to oxygen availability, the Nobel Assembly said.
"They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function," the jury said.
Their research has "paved the way for promising new strategies to fight anemia, cancer and many other diseases."
The jury said the trio had identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen, which is central to a large number of diseases.
"Intense ongoing efforts in academic laboratories and pharmaceutical companies are now focused on developing drugs that can interfere with different disease states by either activating, or blocking, the oxygen-sensing machinery," the jury said.
Kaelin works at the Howard Hughes Medical Institute in the US, while Semenza is director of the Vascular Research Program at the John Hopkins Institute for Cell Engineering.
Ratcliffe is director of clinical research at the Francis Crick Institute in London, and director of the Target Discovery Institute in Oxford.
The three will share the Nobel prize sum of nine million Swedish kronor (about USD 914,000).
They will receive their prize from King Carl XVI Gustaf at a formal ceremony in Stockholm on December 10, the anniversary of the 1896 death of scientist Alfred Nobel who created the prizes in his last will and testament.
Last year, the honour went to immunologists James Allison of the US and Tasuku Honjo of Japan, for figuring out how to release the immune system's brakes to allow it to attack cancer cells more efficiently.
The winners of this year's Physics Prize will be revealed on Tuesday, followed by the Chemistry Prize on Wednesday.
The Literature Prize will be announced on Thursday, with two laureates to be crowned after a sexual harassment scandal forced the Swedish Academy to postpone the 2018 award, for the first time in 70 years.
The Peace Prize will follow on Friday, with bookies predicting a win for Swedish teen climate activist Greta Thunberg on betting sites such as Ladbrokes.
The Economics Prize will wrap up the Nobel prize season on Monday, October 14.
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What is Iran’s 10-point plan? Key demands ahead of US talks in Islamabad
Tehran/Islamabad: Iran has outlined a 10-point plan as the basis for upcoming talks with the United States, expected to begin in Islamabad on April 11, according to a statement from the Iranian Supreme National Security Council.
The plan lays out Tehran’s key political, military and economic demands, and is being seen as a framework for negotiations following the recent escalation in the region.
Strait of Hormuz at the centre
A major focus of the plan is the Strait of Hormuz, a critical global shipping route. Iran has proposed “controlled passage through the Strait of Hormuz in coordination with the Iranian armed forces,” which it says would give the country a unique economic and geopolitical position.
The plan also calls for the “establishment of a safe transit protocol” in the Strait that would guarantee Iran’s dominance under an agreed mechanism.
Call to end conflict
Iran has demanded “the necessity of ending the war against all elements of the axis of resistance,” signalling its expectation that hostilities should stop not only in Iran but also involving allied groups in the region.
US troop withdrawal
Another key demand is the “withdrawal of US combat forces from all bases and deployment points in the region,” indicating Tehran’s long-standing position against American military presence in West Asia.
Sanctions relief and compensation
The plan places strong emphasis on economic measures. It calls for “full payment of Iran’s damages according to estimates,” along with “the lifting of all primary and secondary sanctions and resolutions of the Board of Governors and the Security Council.”
It also seeks “the release of all Iranian assets and properties frozen abroad,” which have been a major point of contention for years.
Binding global guarantee
Finally, Iran has demanded that all these terms be formally recognised through “a binding Security Council resolution,” suggesting it wants international legal backing to ensure enforcement.
What this means
The 10-point plan reflects Iran’s broader push for security guarantees, economic relief and regional influence. The upcoming talks in Islamabad are expected to test how far both sides are willing to negotiate on these demands.
