London: A group of leading UK and US scientists, including Indian-origin Cambridge University immunology and infectious disease expert Ravindra Gupta, on Friday called for more investigation to determine the origin of the COVID-19 pandemic, including the theory of an accidental release from a lab in the central Chinese city of Wuhan.

In a letter published in the journal Science', the experts from world leading universities such as Harvard, Stanford and MIT said knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.

They caution that hypotheses about both natural and laboratory spillovers must be taken seriously until there is sufficient data.

Theories of accidental release from a lab and zoonotic spillover both remain viable, they write.

As scientists with relevant expertise, we agree with the WHO director-general, the United States and 13 other countries, and the European Union that greater clarity about the origins of this pandemic is necessary and feasible to achieve. We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data, they note.

The zoonotic spillover refers to the virus jumping from bats to humans.

Giving a history of the pandemic, the scientists recall how on December 30, 2019, the Program for Monitoring Emerging Diseases notified the world about a pneumonia of unknown cause in Wuhan, China. This led to identifying the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

In May 2020, the World Health Assembly requested that the World Health Organisation (WHO) director-general work with partners to determine the origins of SARS-CoV-2.

In November 2020, the Terms of Reference for a China-WHO joint study were released. The information, data, and samples for the study's first phase were collected and summarised by the Chinese half of the team; the rest of the team built on this analysis.

Although there were no findings in clear support of either a natural spillover or a lab accident, the team assessed a zoonotic spillover from an intermediate host as likely to very likely', and a laboratory incident as extremely unlikely', they note.

Furthermore, the two theories were not given balanced consideration, they caution.

They point to WHO Director-General Tedros Ghebreyesus' comment that the report's consideration of evidence supporting a laboratory accident was insufficient and offered to provide additional resources to fully evaluate the possibility.

A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimise the impact of conflicts of interest. Public health agencies and research laboratories alike need to open their records to the public, the scientists urge.

Finally, in this time of unfortunate anti-Asian sentiment in some countries, we note that at the beginning of the pandemic, it was Chinese doctors, scientists, journalists, and citizens who shared with the world crucial information about the spread of the virus often at great personal cost. We should show the same determination in promoting a dispassionate science-based discourse on this difficult but important issue, they conclude.

The origins of the COVID-19 pandemic remain a widely debated topic, with some scientists and politicians maintaining that the possibility of a lab leak of the deadly virus exists. The Wuhan Institute of Virology (WIV) is near the outbreak's known epicentre of Huanan Seafood Market in Wuhan.

So far, the coronavirus has claimed 3,346,881 lives across the world, along with over 161 million cases, according to Johns Hopkins University.

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Kathmandu (PTI): Rapper-turned-politician Balendra Shah's RSP is all set to form the next government in Nepal after securing sweeping victory in crucial general elections on Saturday, decimating the established parties in the politically fragile nation.

Popularly known as Balen, the 35-year-old prime ministerial candidate of the Rastriya Swatantra Party (RSP) defeated four-time prime minister KP Sharma Oli, the chair of Nepal's legacy party, the Communist Party of Nepal (Unified Marxist–Leninist) -- CPN-UML -- by a huge margin of about 50,000 votes in Jhapa-5 constituency.

Balen, 35, secured 68,348 votes against 74-year-old Oli's 18,734, the Election Commission (EC) said.

He is expected to be the next prime minister of Nepal, reflecting a public mood of rejection of established parties. The RSP, which was formed in 2022 by Ravi Lamichhane, has won 72 seats out of the 90 seats for which results were declared by 9:30 pm, according to the Election Commission (EC).

RSP's seats include a clean sweep in all 10 constituencies of Kathmandu district even as it is leading in 52 seats across the country, the EC data showed.

Legacy parties failed to convince voters for whom the major issues included fighting corruption and an end to nepotism apart from a generational change in political leadership of the Himalayan nation.

The Nepali Congress (NC) won 10 and was leading in eight seats; the CPN-(UML) won just four seats and is leading in eight; the Nepali Communist Party (NCP) won two seats and is leading in five, the Shrama Shakti Party (SSP) was leading in three seats, and the Rastriya Prajatantra Party (RPP) won one seat, the EC data showed. Among the winners is one independent.

Nepal witnessed about 60 per cent voter turnout during the March 5 elections to the House of Representatives. The counting of votes started late Thursday night and as of 9:30 pm Saturday, counting was in progress in the remaining of the total 165 constituencies, the Election Commission said.

The election was being closely watched by India, which is hoping for a stable government in the politically fragile Himalayan nation to take forward the developmental partnership between the two sides.

Prime Minister Narendra Modi on Saturday congratulated the people and government of Nepal for the successful conduct of elections. “It is heartening to see my Nepali sisters and brothers exercise their democratic rights so vibrantly. This historic milestone is a proud moment in Nepal's democratic journey,” Modi said in a post on X.

Modi also said that as a close friend and neighbour, India remains steadfast in its commitment to working closely with the people of Nepal and its new government to scale new heights of shared peace, progress and prosperity.

Oli, who too was projected as the PM face of the CPN-UML, wished Balen for a full five year tenure for his government in the Himalayan nation that has seen 14 governments in the last 18 years.

“Balen babu, congratulations for the victory. I wish your five year tenure be trouble free, successful and hearty congratulations,” Oli wrote in his social media post and attached a 2022 photo showing him gifting a tabla to Balen after the rapper-turned-politician won Kathmandu mayor's election as an independent.

The RSP, which projected Balendra Shah 'Balen' as its prime ministerial candidate and had organised its first election campaign in Janakpur in Madhesh, is heading towards a clean sweep of the province.

‘Balen’, as he is popularly known, projected himself as the “son of Madhesh” during the campaign, with the party launching the campaign with 'Ab ki bar Balendra Sarkar' (This time there will be Balendra’s government) tagline.

Of the total 32 seats in eight districts of Madhesh province, the RSP has won eight and is leading in 22 other constituencies, the EC said.

The party is also making a clean sweep in the Kathmandu Valley winning all 10 seats of Kathmandu district and two in Bhaktapur and two in Lalitpur district.

The party is also leading in the remaining one seat of the Kathmandu Valley with a huge margin, possibly as a result of a massive road show led by Balen in all 15 constituencies on the last day of the election campaign.

RSP chairman Lamichhane won with a huge margin from Chitwan-2 constituency, marking his third consecutive victory with 54,402 votes against his nearest rival NC's Mina Kumari Kharel, who received 14,564 votes.

According to the Election Commission, former prime minister and NCP leader Pushpa Kamal Dahal Prachanda won from Rukum Purba district by securing 10,240 votes against his rival Lilamani Gautam of CPN-(UML), who got 3,462 votes.

RPP's Gyanendra Shahi won from the Jumla constituency of Karnali province by defeating his closest rival Naresh Bhandari of the NCP and became the only candidate of the pro-monarchist RPP to have secured a seat in the House of Representatives.

The election also saw 10 women candidates win, nine of them from the RSP while one from NC.

Meanwhile, the RSP is also leading in proportional voting system with the party bagging 474,266 votes followed by Nepali Congress with 160,384. The CPN (UML) has received 127,841, Nepali Communist Party 65,363, the RPP 34,154, and Shrama Shakti Party 17,437 votes till now.

Out of a total of 275 members of the Parliament, 165 are being elected through direct voting, while the remaining 110 through a proportionate method.

Around 3,400 candidates were vying for 165 seats under direct voting, and 3,135 candidates for 110 seats through proportionate voting.

The Gen Z youth, through their two-day intensified protests on September 8 and 9 last year, ousted Prime Minister Oli of the CPN-(UML), who was heading a coalition government with the backing of Nepali Congress that enjoyed nearly two-thirds majority support.

Though Balen was a popular choice to lead the interim government after Oli's ouster, he declined to lead the interim administration, saying he would prefer to contest the parliamentary election for a full term.

In January, he joined the RSP and was soon declared the party's prime ministerial candidate.

The major issues raised by Gen Z before and during the election campaign were anti-corruption, good governance, an end to nepotism, generational change in political leadership, etc.

Sunil Babu Pant, former MP and a political analyst, said, “The victory of Rastriya Swatantra Party in the March 5 elections and the expectation that Balen Shah could emerge as Nepal's next Prime Minister reflects the people's deep rooted frustration with the old political order and their hope for a new direction.”

“As Balen assumes the country's leadership, his first responsibility must be to demonstrate that corruption will not be tolerated under any circumstances,” he said.

Balen will also face a complex geopolitical challenge, Pant said, adding, “He must prove that he is not a puppet of any external power, western or otherwise. Nepal's leadership must carefully balance relations with all global actors and pursue an independent foreign policy that prioritises the national interest.”