WHO issues product alert over contaminated syrup by Indian manufacturer
United Nations, Apr 25: The World Health Organisation on Tuesday issued a product alert over contaminated syrup by an Indian manufacturer, warning that it is unsafe for use, especially in children, and may result in serious injury or death.
The WHO Medical Product Alert refers to a batch of substandard (contaminated) Guaifenesin syrup TG syrup identified in the Marshall Islands and Micronesia (Federated States of) and reported to WHO on April 6, 2023.
The stated manufacturer of the affected product is QP Pharmachem Ltd (Punjab, India). The stated marketer of the product is Trillium Pharma (Haryana, India). To date, neither the stated manufacturer nor the marketer have provided guarantees to WHO on the safety and quality of these products.
"The substandard product referenced in this Alert is unsafe and its use, especially in children, may result in serious injury or death. Toxic effects can include abdominal pain, vomiting, diarrhoea, inability to pass urine, headache, altered mental state and acute kidney injury which may lead to death," the alert said.
There was no immediate comment from the manufacturer on the WHO alert.
Guaifenesin is an expectorant used to relieve chest congestion and the symptoms of cough.
Samples of the Guaifenesin syrup TG syrup from the Marshall Islands were analysed by quality control laboratories of the Therapeutic Goods Administration (TGA) of Australia. The analysis found that the product contained unacceptable amounts of diethylene glycol and ethylene glycol as contaminants.
The product referenced in this alert may have marketing authorisations in other countries in the Western Pacific region. It may have also been distributed, through informal markets, to other countries or regions, the alert by the global health agency said.
The alert said that Diethylene glycol and ethylene glycol are toxic to humans when consumed and can prove fatal.
Who advised that if people have the affected product, they should not use it.
WHO requests increased surveillance and diligence within the supply chains of countries and regions likely to be affected by these products. Increased surveillance of the informal/unregulated market is also advised. National regulatory authorities/health authorities are advised to immediately notify WHO if these substandard products are discovered in their respective country.
Manufacturers of liquid dosage forms, especially syrups that contain excipients including propylene glycol, sorbitol, and/or glycerin/glycerol, are urged to test for the presence of contaminants such as ethylene glycol and diethylene glycol before use in medicines.
Healthcare professionals should report any suspicious cases of adverse events linked to the use of these contaminated medicines to the National Regulatory Authorities/ National Pharmacovigilance Centre, it said.
Recently, questions have been raised over the quality of drugs manufactured by India-based companies. In February, the Tamil Nadu-based Global Pharma Healthcare recalled its entire lot of eye drop allegedly linked to vision loss in the US.
Before that, India-made cough syrups were allegedly linked to children deaths in the Gambia and Uzbekistan last year.
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Blast at railway track in Patiala was attempted detonation, killed operator: Punjab Police
Chandigarh (PTI): A blast that took place at a railway track near the Shambhu area in Punjab's Patiala was an attempted detonation, a senior police officer said on Tuesday.
The person who was trying to carry out the detonation on Monday has died, Patiala SSP Varun Sharma said.
The blast took place near the Shambhu-Ambala rail track. Police earlier said that an unidentified body, which was blown into pieces, was recovered from the spot.
Initially, it was considered a low-intensity blast. However, investigation has revealed that it was an attempted detonation.
The explosion occurred at around 10 pm at the rail track dedicated for freight trains, police said.
The explosion also caused some damage to the track.
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"Late night, we had received information about a low intensity explosion at a railway track near Shambhu-Haryana border. Immediately, I, along with the deputy inspector general of police and other senior officials, rushed to the spot to take stock of the situation.
"We found that it was not a low intensity explosion but an attempted detonation," the SSP said.
During the attempt, the person who was trying to carry out the detonation died, and his body has been recovered, he said.
Police said they have recovered a SIM card from the spot.
"After getting whatever scientific evidence including a SIM card from the spot, police have launched technical investigation," Sharma said.
"We expect that we will soon unravel the whole conspiracy," he said.
He further said the Government Railway Police, the Railway Protection Force and other agencies are involved in investigation.
Earlier in January, a blast on a dedicated freight corridor railway track in the Fatehgarh Sahib district's Sirhind had damaged the engine of a train and left a loco pilot injured.
