Diet change combined with drugs may cut seizures by half: AIIMS study
New Delhi (PTI): Following a modified Atkins diet high in fat and low in carbohydrates and taking medication may reduce seizures by over half in people with tough-to-treat epilepsy, according to a study by researchers at the All India Institute of Medical Sciences.
The modified Atkins diet is a combination of the Atkins diet and a ketogenic diet that includes food items such as soy products, heavy cream, butter and oils, leafy green vegetables, and animal protein including eggs, chicken, fish, and bacon.
While the ketogenic diet has been shown to be effective in reducing seizures, its stringent requirements and restrictions can make it difficult to follow, the researchers said.
"For people with drug-resistant epilepsy, or those who have been unable to find effective treatment to reduce seizures, it's encouraging to see that there are lifestyle changes that can be combined with standard drug therapy to reduce the number of seizures," said Manjari Tripathi, from AIIMS New Delhi.
"Our study found that this combination may reduce the chance of seizures by more than half," said Tripathi, author of the study published in the journal Neurology.
The study involved 160 adults and adolescents who had epilepsy for more than 10 years on average and had at least 27 seizures per month despite trying an average of four antiseizure medications at the maximum tolerated dose.
They were randomly assigned to receive either standard drug therapy alone or drugs plus the modified Atkins diet over six months. Participants logged their seizures and meals.
They were given food lists, sample menus and recipes. Carbohydrate intake was restricted to 20 grams per day. US Federal dietary guidelines recommend between 225 and 325 grams of carbs per day.
After six months, researchers found that 26 per cent of people who had both drug therapy and followed the modified Atkins diet had more than a 50 per cent reduction in seizures compared to only three per cent of the people who had drug therapy alone.
Four people in the diet group were free of seizures by the end of the study, while no one in the medication-only group was seizure-free, the researchers found.
The study also looked at quality of life, behaviour and side effects at six months.
The group that had drug therapy and followed the modified Atkins diet showed an improvement in all areas compared to the group that had drug therapy alone, the researchers said.
They noted that 33 per cent of the participants did not complete the study due to poor tolerance of the diet, lack of benefit or the inability to follow-up in part due to COVID-19.
However, the researchers said tolerance of the modified Atkins diet was better than what is seen with the ketogenic diet.
"While the modified Atkins diet may be an effective treatment in controlling seizures, further research is needed to identify genetic biomarkers and other factors associated with the response to this diet," Tripathi added.
"This may improve patient care by encouraging targeted precision based earlier use of this diet," she added.
The researchers acknowledged a limitation in the study that seizures were self-reported or reported by caregivers, so some of them may not have been reported at all.
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BJP will win more seats in 2024 LS polls than in 2019: Tejasvi Surya
Meerut (UP) (PTI): Bharatiya Janata Yuva Morcha (BJYM) president Tejasvi Surya claimed on Tuesday that the BJP will get more seats in next year's Lok Sabha polls compared to the 2019 general election.
He also said the "double-engine" government led by the Bharatiya Janata Party (BJP) has changed the face of Uttar Pradesh.
Addressing a BJYM convention in Meerut, Surya said, "The BJP will get more seats in the 2024 polls than in 2019 and (Prime Minister Narendra) Modiji will score a hat-trick for a third innings."
The member of Parliament from Bangalore South also alleged that before 2014, when the Modi government came to power, there was a misrule in the country, adding that nine years of the Modi government have proved to be more effective than the 70 previous years. People's welfare is the topmost priority of this government, he said.
Surya said the "double-engine" government has changed the face of Uttar Pradesh, adding that thanks to Prime Minister Modi and Chief Minister Yogi Adityanath, the law-and-order scenario of the state has also improved.
"Double engine" is a term often used by BJP leaders to refer to the saffron party being in power at the Centre as well as in a state.
Surya said under Modi's leadership, India has got respect at the global stage, which is only increasing.
The prime minister is trying to take the country to new heights, he added.
