London, Apr 7: People infected with SARS-CoV-2, the virus that causes COVID-19, have an increased risk of developing serious blood clots for up to six months after the infection, even in mild cases, according to a study published in The BMJ.
The researchers found an increased risk of deep vein thrombosis -- a blood clot in the leg -- up to three months after COVID-19 infection, pulmonary embolism -- a blood clot in the lung -- up to six months, and a bleeding event up to two months.
They also show a higher risk of events in patients with underlying conditions, patients with more severe COVID-19, and during the first pandemic wave compared with the second and third waves.
The researchers from Umea University in Sweden noted that these results support measures to prevent thrombotic events, especially for high risk patients, and strengthen the importance of vaccination against COVID-19.
Using national registries in Sweden, they identified more than one million people with confirmed SARSCoV-2 infection between February 1, 2020 and May 25, 2021, matched by age, sex, and county of residence to more than four million people who had not had a positive SARS-CoV-2 test result.
The researchers first calculated the rates of deep vein thrombosis, pulmonary embolism, and bleeding in COVID-19 individuals during a control period -- before and long after COVID-19 diagnosis -- and compared it to the rates in different time intervals after COVID-19 diagnosis.
They then calculated the rates of deep vein thrombosis, pulmonary embolism, and bleeding 1-30 days after COVID-19 diagnosis in the COVID-19 group and compared them to the corresponding rates in the control group.
The results show that compared with the control period, risks were significantly increased 90 days after COVID-19 for deep vein thrombosis, 180 days for pulmonary embolism, and 60 days for bleeding.
After taking account of a range of potentially influential factors, the researchers found a five-fold increase in risk of deep vein thrombosis, a 33-fold increase in risk of pulmonary embolism, and an almost twofold increase in risk of bleeding in the 30 days after infection.
This means that a first deep vein thrombosis occurred in 401 patients with COVID-19 and 267 control patients, the researchers said.
A first pulmonary embolism event occurred in 1,761 patients with COVID-19 and 171 control patients, and a first bleeding event occurred in 1,002 patients with covid-19 and 1,292 control patients, they said.
The researchers found that the risks were highest in patients with more severe COVID-19 and during the first pandemic wave compared with the second and third waves, which they said could be explained by improvements in treatment and vaccine coverage in older patients after the first wave.
Even among mild, non-hospitalised COVID-19 patients, the researchers found increased risks of deep vein thrombosis and pulmonary embolism.
No increased risk of bleeding was found in mild cases, but a noticeable increase was observed in more severe cases.
This is an observational study, so the researchers cannot establish cause, and they acknowledge several limitations which might have affected their findings.
For example, they said VTE may have been underdiagnosed in patients with COVID-19, testing for the disease was limited, especially during the first pandemic wave, and information on vaccination was not available.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
Bengaluru (PTI): Senior politician Basavaraj Horatti, who recently resigned as the Chairman of Karnataka Legislative Council and MLC, on Wednesday joined the BJP.
He joined the party in the presence of Chief Minister Basavaraj Bommai, former Chief Minister Jagadish Shettar, BJP national General Secretary C T Ravi, Ministers R Ashoka, Govind Karjol, C C Patil among others.
"Basavaraj Horatti has been a member of the Legislative Council for nearly 45 years and has served as its Chairman and Minister. He is a leader with lot of experience, commands a lot of respect and has been working for the cause of teachers. After deciding to join BJP he met Union Home Minister Amit Shah and resigned from his post and has officially joined the party today," Bommai said.
Speaking to reporters after welcoming the senior leader, he said, BJP is organising a huge programme in Hubballi shortly, to mark his induction into the party.
"His joining has strengthened the party. No one has the record of being an MLC for such a long time in the entire country. It has strengthened the party especially in the north Karnataka region. We will use his experience and will give him all the opportunities and respects he deserves," he added.
With this, Horatti, who has been elected as MLC seven successive times from 1980, has ended his long association with the JD(S).
He is likely to be fielded as the BJP's candidate for the upcoming MLC polls from West Teachers' constituency. Considered to be the senior-most MLC, the 76-year-old was seen as a prominent Lingayat face of the JD(S) from north Karnataka.
He had been education minister in the state, and was elected as the Chairman of the Legislative Council in February 2021.