Revolutionary Research on Personalized Cancer Treatment Using Zebrafish Avatar discussed at GMU
Ajman (Press Release): Gulf Medical's University and Thumbay Research Institute of Precision Medicine marked the Research Day, sharing insights from leading minds on the region’s first pilot research on personalized precision medicine programme using the Zebrafish Avatars to treat cancer- with the first phase focusing on the care of patients suffering from colorectal and breast cancer. The study’s findings aim to help researchers and oncology healthcare providers to design more tailored and effective treatments based on genetic screening, data on tumor progression and subsequently assessing the need and efficacy of chemotherapy versus other advanced surgical alternatives. In this way, the research further intends to reduce the trial-and-error response in oncology medicine combined with the preservation of organ function and, improve the overall quality of life.
Dr. Rita Fior, PhD, Group Leader Champalimaud Center for the Unknown, elaborated, “The research has been conducted by developing Zebrafish xenografts with a very clear goal of personalized medicine. We live in a world with such amazing technology that helps us to go to the moon, fly planes, zoom over the world, advanced technologies in biology, sequencing of whole genomes, etc. However, once a patient is diagnosed with cancer, they are most likely to be treated with chemo or radiotherapy- although many new amazing targeted therapies are being developed and great advances have been made. By directly challenging the cells and measuring the response to direct perturbation, we have found good predictive analysis that can aid the entire process of diagnostics, therapy, and tailor it to the needs of the specific
individual.”
An avatar is an animal that has been incubated with a person’s cancer cells so that doctors can test drug effectiveness on the animal tumor first. With several avatars, doctors can test several treatments. But obtaining a tumor assay from a mouse avatar could take months. And people fighting cancer don’t have months. In recent times, the Zebrafish has successfully created human cancer avatars where the tumors are ready to be assayed in just four days.
Speaking about the research, Professor Hossam Hamdy, chancellor, Gulf Medical University, said, “As the leading health professions’ education institution in UAE, Gulf Medical University looks forward to playing a central role in the advancement of oncology diseases research landscape, incorporating the rich multi-factorial data to tailor treatment and significantly reduce the risks associated with chemotherapy. We are confident that our work will contribute to UAE’s efforts in spearheading the growth and development of the healthcare sector.”
On similar lines, Prof. Salem Chouaib, Director of the Thumbay Research Institute for Precision Medicine, stated, “In every area of cancer, treatments have largely functioned on a one-size-fits-all basis because we didn’t have tools to do any better. Going forward, the advancements in precision medicine will help in determining whether patients are likely to benefit from a particular therapy, longer survival and fewer toxic effects of chemotherapy.”
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Grok obscene AI content: X submits response, IT Ministry examining it, say sources
New Delhi (PTI): The IT Ministry is examining the response and submissions made by X following a government directive to crack down on misuse of artificial intelligence chatbot Grok by users for the creation of sexualised and obscene images of women and minors, sources said.
X had been given extended time until Wednesday, 5 PM to submit a detailed Action Taken Report to the ministry, after a stern warning was issued to the Elon Musk-led social media platform over indecent and sexually-explicit content being generated through misuse of AI-based services like 'Grok' and other tools.
Sources told PTI that X has submitted their response, and it is under examination.
The details of X's submission were, however, not immediately known.
On Sunday, X's 'Safety' handle said it takes action against illegal content on its platform, including Child Sexual Abuse Material (CSAM), by removing it, permanently suspending accounts, and working with local governments and law enforcement as necessary.
"Anyone using or prompting Grok to make illegal content will suffer the same consequences as if they upload illegal content," X had said, reiterating the stance taken by Musk on illegal content.
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On January 2, the IT Ministry pulled up X and directed it to immediately remove all vulgar, obscene and unlawful content, especially generated by Grok (X's built-in artificial intelligence interface) or face action under the law.
In the directive on Friday, the ministry asked the US-based social media firm to submit a detailed action taken report (ATR) within 72 hours, spelling out specific technical and organisational measures adopted or proposed in relation to the Grok application; the role and oversight exercised by the Chief Compliance Officer; actions taken against offending content, users and accounts; as well as mechanisms to ensure compliance with the mandatory reporting requirement under Indian laws.
The IT Ministry, in the ultimatum issued, noted that Grok AI, developed by X and integrated on the platform, is being misused by users to create fake accounts to host, generate, publish or share obscene images or videos of women in a derogatory or vulgar manner.
"Importantly, this is not limited to creation of fake accounts but also targets women who host or publish their images or videos, through prompts, image manipulation and synthetic outputs," the ministry said, asserting that such conduct reflects a serious failure of platform-level safeguards and enforcement mechanisms, and amounts to gross misuse of artificial intelligence (AI) technologies in violation of stipulated laws.
The government made it clear to X that compliance with the IT Act and rules is not optional, and that the statutory exemptions under section 79 of the IT Act (which deals with safe harbour and immunity from liability for online intermediaries) are conditional upon strict observance of due diligence obligations.
"Accordingly, you are advised to strictly desist from the hosting, displaying, uploading, publication, transmission, storage, sharing of any content on your platform that is obscene, pornographic, vulgar, indecent, sexually explicit, paedophilic, or otherwise prohibited under any law...," the ministry said.
The government warned X in clear terms that any failure to observe due diligence obligations shall result in the loss of the exemption from liability under section 79 of the IT Act, and that the platform will also be liable for consequential action under other laws, including the IT Act and Bharatiya Nyaya Sanhita.
It asked X to enforce user terms of service and AI usage restrictions, including ensuring strong deterrent measures such as suspension, termination and other enforcement actions against violating users and accounts.
X has also been asked to remove or disable access "without delay" to all content already generated or disseminated in violation of applicable laws, in strict compliance with the timelines prescribed under the IT Rules, 2021, without, as such, vitiating the evidence.
Besides India, the platform has drawn flak in the UK and Malaysia too. Ofcom, the UK's independent communications regulator, in a recent social media post, said: "We are aware of serious concerns raised about a feature on Grok on X that produces undressed images of people and sexualised images of children".
"We have made urgent contact with X and xAI to understand what steps they have taken to comply with their legal duties to protect users in the UK. Based on their response, we will undertake a swift assessment to determine whether there are potential compliance issues that warrant investigation," Ofcom said.
