Revolutionary Research on Personalized Cancer Treatment Using Zebrafish Avatar discussed at GMU
Ajman (Press Release): Gulf Medical's University and Thumbay Research Institute of Precision Medicine marked the Research Day, sharing insights from leading minds on the region’s first pilot research on personalized precision medicine programme using the Zebrafish Avatars to treat cancer- with the first phase focusing on the care of patients suffering from colorectal and breast cancer. The study’s findings aim to help researchers and oncology healthcare providers to design more tailored and effective treatments based on genetic screening, data on tumor progression and subsequently assessing the need and efficacy of chemotherapy versus other advanced surgical alternatives. In this way, the research further intends to reduce the trial-and-error response in oncology medicine combined with the preservation of organ function and, improve the overall quality of life.
Dr. Rita Fior, PhD, Group Leader Champalimaud Center for the Unknown, elaborated, “The research has been conducted by developing Zebrafish xenografts with a very clear goal of personalized medicine. We live in a world with such amazing technology that helps us to go to the moon, fly planes, zoom over the world, advanced technologies in biology, sequencing of whole genomes, etc. However, once a patient is diagnosed with cancer, they are most likely to be treated with chemo or radiotherapy- although many new amazing targeted therapies are being developed and great advances have been made. By directly challenging the cells and measuring the response to direct perturbation, we have found good predictive analysis that can aid the entire process of diagnostics, therapy, and tailor it to the needs of the specific
individual.”
An avatar is an animal that has been incubated with a person’s cancer cells so that doctors can test drug effectiveness on the animal tumor first. With several avatars, doctors can test several treatments. But obtaining a tumor assay from a mouse avatar could take months. And people fighting cancer don’t have months. In recent times, the Zebrafish has successfully created human cancer avatars where the tumors are ready to be assayed in just four days.
Speaking about the research, Professor Hossam Hamdy, chancellor, Gulf Medical University, said, “As the leading health professions’ education institution in UAE, Gulf Medical University looks forward to playing a central role in the advancement of oncology diseases research landscape, incorporating the rich multi-factorial data to tailor treatment and significantly reduce the risks associated with chemotherapy. We are confident that our work will contribute to UAE’s efforts in spearheading the growth and development of the healthcare sector.”
On similar lines, Prof. Salem Chouaib, Director of the Thumbay Research Institute for Precision Medicine, stated, “In every area of cancer, treatments have largely functioned on a one-size-fits-all basis because we didn’t have tools to do any better. Going forward, the advancements in precision medicine will help in determining whether patients are likely to benefit from a particular therapy, longer survival and fewer toxic effects of chemotherapy.”
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Allu Arjun didn't leave theatre despite being told about woman's death: Hyderabad police
Hyderabad, Dec 22: Top Telugu actor Allu Arjun did not leave the theatre during the screening of 'Pushpa-2' on December 4 despite being told to do so in view of a stampede in which a woman died, police officials claimed on on Sunday.
Speaking at a press conference on the annual round-up of 2024, city police commissioner C V Anand showed a video, made by police, on the situation that prevailed when the stampede occurred.
The video was made by collating footage, including from news channels and cell phone clips. It suggests the actor remained in the theatre till the midnight.
Anand did not make any comment on the video, but said the media can draw its own conclusions.
A police official talked about the sequence of events on the fateful night of December 4.
He said that he and other police officials informed a manager of Allu Arjun about the death of the woman and told him that the situation was out of control. He indicated that they were not allowed to meet the actor.
Allu Arjun's staff members told them that they would convey the matter to the actor but did not do so, he said.
The official said he later managed to reach the actor, told him about the woman's death and asked him to leave the theatre so that the fans don't harm each other while trying to catch a glimpse of him.
The official also told the actor that security arrangements would be made for his exit.
However, the actor said he would go only after watching the film, the police official said.
Later, accompanied by a senior officer, the official went inside and brought the actor out, he said.
Amid allegations that bouncers hired by Allu Arjun pushed crowds as well as policemen when the stampede occurred at the cinema hall, the police commissioner warned that stringent action as per law would be taken if THE bouncers indeed misbehaved with the police on duty.
The VIPs would be made responsible for the behaviour of the bouncers hired by them, he said.
Asked if the police would appeal against the interim bail granted to Allu Arjun, the commissioner refused to give a direct response, just saying it is part of the investigation.
What course of action is taken would be known in the days to come, he said.
He also declined to comment when asked if the family of the deceased told him about Allu Arjun's team or film production team allegedly threatening them not to speak on the issue.
Meanwhile, state Cinematography Minister Komatireddy Venkat Reddy found fault with Allu Arjun responding on Saturday to the debate in the Legislative Assembly.
The minister, who observed that the actor should have respect for the government and the chief minister, demanded an apology from Allu Arjun to the government and the CM.
"This government is never vindictive. As Cinematography Minister, we allowed benefit shows and hiking ticket prices to promote the film industry," he said.
However, Union Minister of State for Home Bandi Sanjay Kumar found fault with CM Revanth Reddy for his comments on Allu Arjun in the Assembly on Saturday.
The comments of the CM sounded like character assassination of Allu Arjun and hurting the Telugu film industry, he alleged in a statement.
Later in the day, Sanjay Kumar visited a boy who is undergoing treatment in a hospital after being injured in the stampede.
"Consoled his father over the heartbreaking loss of his wife, Revathi. I pray to god that Sritej recovers at the earliest. Assured support to the family in this difficult time," Kumar said on X.
Earlier in the day, state DGP Jitender told reporters in Karimnagar district that film personalities and all others should understand that safety and security of citizens is utmost important, and also conduct themselves accordingly.
