Novel regenerative bandage may heal diabetics' wounds faster
New York, June 12: Your painful, hard-to-treat sores may soon be a thing of the past as scientists have developed a regenerative bandage that may quickly heal them without using drugs, an advance which may help make healing of wounds in diabetics faster.
The study, published in the journal Proceedings of the National Academy of Sciences, showed that the bandage healed diabetic wounds 33 per cent faster than one of the most popular bandages currently on the market.
"The novelty is that we identified a segment of a protein in skin that is important to wound healing, made the segment and incorporated it into an antioxidant molecule that self-aggregates at body temperature to create a scaffold that facilitates the body's ability to regenerate tissue at the wound site," said lead author Guillermo Ameer from the Northwestern University in Illinois, US.
The logic behind the regenerative bandage is laminin -- a protein found in most of the body's tissues including the skin.
Laminin sends signals to cells, encouraging them to differentiate, migrate and adhere to one another. The team identified a segment of laminin -- 12 amino acids in length -- called A5G81 that is critical for the wound-healing process.
They incorporated A5G81 into an antioxidant hydrogel bandage that it previously developed in the laboratory. The antioxidant nature also helps counters inflammation.
Hydrogel liquid can form the exact shape of the wound which makes this bandage better than others.
"Wounds have irregular shapes and depths. Our liquid can fill any shape and then stay in place. Other bandages are mostly based on collagen films or sponges that can move around and shift away from the wound site," Ameer said.
The team also used animal models to test the effectiveness and found no adverse effects of the bandage on the animals.
Ameer also added that their bandage can be rinsed off with cool saline, so the regenerating tissue remains undisturbed.
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Jhansi fire: Nurse's heroic efforts helped save over dozen babies
Lucknow/Jhansi (UP), Nov 17: Nurse Megha James was on duty when the fire broke out at the Jhansi hospital and she threw herself headlong into the rescue efforts, playing a hero's role by saving several babies.
Even when her salwar got burned, she refused to give up and was able to evacuate 14-15 babies with others' help.
"I had gone to take a syringe to give an injection to a child. When I came back, I saw that the (oxygen) concentrator had caught fire. I called the ward boy, who came with the fire extinguisher and tried to put it out. But by then, the fire had spread," James said.
Ten babies perished in a fire that broke out at the Neonatal Intensive Care Unit of the Maharani Laxmi Bai Medical College in Jhansi Friday night.
Faced with an enormous blaze, James's mind worked with a frenetic speed, to the extent she cared little about burning herself.
"My chappal caught fire and I burned my foot. Then my salwar caught fire. I removed my salwar and discarded it. At that time, my mind was virtually not working," she told PTI Videos.
James just wore another salwar and went back to the rescue operation.
"There was a lot of smoke, and once the lights went out, we could not see anything. The entire staff brought out at least 14-15 children. There were 11 beds in the ward with 23-24 babies," she said.
Had the lights not gone out they could have saved more children, James said. "It all happened very suddenly. None of us had expected it."
Assistant Nursing Superintendent Nalini Sood praised James's valour and recounted bits from how the rescue operation was carried out.
"The hospital staff broke the glasses of the NICU ward to evacuate the babies. It was then Nurse Megha's salwar caught fire. Instead of caring for her safety, she stayed there to rescue the babies and handed them over to people outside," she said.
Sood said James is currently undergoing treatment at the same medical college. She said she did not know the extent of her burns.
"The rescued babies were shifted to a ward very close to the NICU ward… When I recall the scene, I feel like crying," she said.
Dr Anshul Jain, the head of the anaesthesiology department at the medical college, explained the standard rescue operation and claimed the hospital followed the protocol to the T.
"In the triage process during an ICU evacuation, the policy is to evacuate less-affected patients first. The rationale behind this approach is that patients requiring minimal support can be relocated quickly, enabling a larger number of evacuations to be completed in a shorter time.
"In contrast, patients on ventilators or requiring high oxygen support demand more time and resources for evacuation," he said.
"This principle was successfully implemented in Jhansi, playing a significant role in saving many lives," Jain said.
A newborn rescued from the fire died due to illness on Sunday, Jhansi District Magistrate Avinash Kumar said.
