COVID-19 ICU patients at risk of acute brain dysfunction, says study
New Delhi: COVID-19 patients admitted to intensive care in the early months of the pandemic experienced a higher burden of delirium and coma than is typically found in those hospitalized with acute respiratory failure, according to the largest study of its kind to date.
The research, published in The Lancet Respiratory Medicine journal, tracked the incidence of delirium and coma in over 2,000 COVID-19 patients admitted before April 28, 2020, to 69 adult intensive care units across 14 countries.
According to the scientists, led by those at Vanderbilt University Medical Center in the US, the choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients.
They said ICU delirium is associated with higher medical costs and greater risk of death and long-term ICU-related dementia.
Nearly 82 percent of the patients in the study were comatose for a median of 10 days, and 55 percent were delirious for a median of three days.
The scientists noted that acute brain dysfunction lasted for an average of 12 days.
"This is double what is seen in non-COVID ICU patients," said study co-author Brenda Pun from VUMC.
The scientists believe COVID-19 could predispose patients to a higher burden of acute brain dysfunction.
However, they also noted that patient care factors, some of which are related to pressures posed on health care by the pandemic, also appear to have played a significant role.
With respect to COVID-19, the scientists believe there has been widespread abandonment of newer clinical protocols that are proven to help ward off the acute brain dysfunction that usually affects many critically ill patients.
"It is clear in our findings that many ICUs reverted to sedation practices that are not in line with best practice guidelines and we're left to speculate on the causes," Pun said.
"Early reports of COVID-19 suggested that the lung dysfunction seen required unique management techniques including deep sedation. In the process, key preventive measures against acute brain dysfunction went somewhat by the boards," she added.
Analyzing patient characteristics from electronic health records, and care practices, and findings from clinical assessments, the scientists found that about 90 percent of patients tracked in the study were invasively mechanical ventilated at some point during hospitalization, and 67 percent on the day of ICU admission.
Patients receiving benzodiazepine sedative infusions were at 59 percent higher risk of developing delirium, they added.
In comparison, the patients who received family visitation were at 30 percent lower risk of delirium, the study noted.
"There's no reason to think that, since the close of our study, the situation for these patients has changed," said study senior author, Pratik Pandharipande.
"These prolonged periods of acute brain dysfunction are largely avoidable. ICU teams need above all to return to lighter levels of sedation for these patients, frequent awakening and breathing trials, mobilization, and safe in-person or virtual visitation," Pandharipande added.
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Trump arrives in China for talks with Xi
Beijing (PTI): US President Donald Trump arrived in China on Wednesday for a three-day state visit during which he will discuss a host of global issues, including the Iran war, with Chinese President Xi Jinping.
Trump, who is visiting China at the invitation of President Xi, was received by Chinese Vice President Han Zheng at the airport.
The leaders of the world's two largest economies will hold their seventh face-to-face talks. They last met face-to-face in October 2025 in Busan, South Korea.
The US President arrived in China on his second visit in nine years to clinch a trade deal, to end the frictions over tariffs that affected its over USD 525 billion exports to the US.
Trump, who is accompanied by top CEOs, was the last US president to visit China in 2017, during his first term.
President Trump would have a bilateral meeting with Xi on Thursday, US Principal Deputy Press Secretary Anna Kelly said on Sunday.
The two leaders will meet again on Friday for a bilateral tea and working lunch, she said, adding that the US plans to host the Chinese leader for a reciprocal visit later this year.
Ahead of Trump's arrival, Chinese Vice-Premier He Lifeng and Scott Bessent completed the final round of trade negotiations in South Korea, details of which are not known.
The talks focused on trade and tariffs, Artificial Intelligence and technology, Taiwan and US' arms sales to Taipei, Iran and West Asia security and rare earths and supply chains.
Trump's schedule included a visit to the Temple of Heaven, a complex of imperial temples where emperors would pray for a good harvest.
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Ahead of his departure for Beijing, Trump told the media in Washington he would be talking with Xi about trade more than anything else.
He plans to sign more deals with China to buy more American food and aircraft. The two countries also plan to set up a Board of Trade with China to address differences between the countries.
From a trade point of view, China looks to reap a rich harvest as Trump is accompanied by top CEOs of US multinational giants, including Tesla chief Elon Musk and Apple CEO Tim Cook, who have well-entrenched business in China.
Apple has regained the top spot in China's competitive smartphone market as of early 2026, driven by a 28 per cent surge in iPhone shipments.
In April, Tesla's China-made vehicle sales (including exports) reached 79,478, a 36 per cent year-over-year increase, signalling a production rebound.
The top US business leaders will be allowed to mingle with their Chinese counterparts at an exclusive international business club, according to Chinese officials.
The global focus on the summit, however, would be on any possible outcome that could end the US-Israeli-Iran war and end the blockade of the Strait of Hormuz.
Ahead of Trump's visit, Iranian Foreign Minister Abbas Araghchi made his first visit to Beijing after the war and held talks with his Chinese counterpart Wang Yi.
The US watched his visit closely as China is the largest importer of Iranian oil and shares strategic defence ties with Tehran, and has considerable influence over Iran.
After talks with Araghchi, Wang called on Iran to reopen the Strait of Hormuz as soon as possible, even as it appreciated Tehran's commitment not to develop nuclear weapons, a prime demand of Trump to end the war.
Commenting on Wang-Araghchi talks, US Secretary of State Marco Rubio said, "I hope the Chinese tell him what he needs to be told. And that is what you are doing in the Strait, which is causing you to be globally isolated. You're the bad guy in this."
China's anxieties over the Gulf war increased, especially after Trump imposed a blockade of Iranian ports, restricting Iran's oil exports to China.
Bert Hoffman, former World Bank country director for China, said China wants the Iran war to end because it has many partners in the region, including Saudi Arabia, the UAE and Kuwait. "So they don't like to see wars, they like to have stability," he said.
In its editorial on Trump's visit, state-run Global Times said Xi has held multiple telephone conversations and meetings with him, which have helped correct the course of the bilateral relationship and steer it clear of hidden dangers at critical moments.
For China-US relations to truly stabilise and improve in the future, the most fundamental step is to fully and faithfully implement the important consensus reached by both leaders, it said.
From China's point of view, the Taiwan issue was expected to figure prominently in the talks.
Last week, China's Foreign Minister Wang told US Secretary of State Marco Rubio, during their telephone talks, that the US should make the right choice about the self-ruled Taiwan.
China claims Taiwan as part of its own and has been ramping up military pressure on the island with periodic military drills around the island.
VIDEO | Beijing: US President Donald Trump arrives in China for high stakes meeting with Chinese President Xi Jinping.
— Press Trust of India (@PTI_News) May 13, 2026
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