Decoded: Which brain region helps us stay conscious?
New York, June 22: Scientists, including one of Indian-origin, have found that a brain region -- associated with cognitive behaviours, decision making, and moderating social behaviour -- determines our overall level of consciousness.
The study, conducted on rats, provided evidence that the prefrontal cortex has a switchboard-like relationship with other areas of the brain, helping to ignite awareness of visual information.
"The study suggests that the prefrontal cortex has the potential to play a role in coordinating the level of consciousness," said George Mashour from the University of Michigan.
The results could also be explored for applications in people with disorders of consciousness, such as coma or vegetative states.
"It's very difficult and dangerous to directly intervene at the level of arousal centres in the brainstem because of its location, small size, and nearby vital functions.
"Maybe the prefrontal cortex is an accessible gateway to some of those other arousal systems that could be leveraged in a clinical setting outside of anesthesia," he said.
In the study, published in the journal Current Biology, the team gave anesthetised rats with a common anesthetic used in humans and exposed their prefrontal and parietal lobe -- a brain region associated with processing sensory information and interpreting visual information -- to drugs that ramped up the effect of neurotransmitters and measured their brain activity and behaviour.
To see what had the causal power to take an unconscious brain receiving ongoing anesthesia and wake it up, the team targeted two neurotransmitters that are associated with wakefulness: acetylcholine and norepinephrine, said Dinesh Pal, from the varsity.
The findings showed that when exposed to an acetylcholine-receptor activator, the rats' brain waves -- normally slow during sleep and anesthesia -- sped up.
But rats were able to start behaving as though they were awake only with prefrontal cortex stimulation, all while continuing to receive the same level of anesthesia that is used clinically for surgery in humans.
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Jhansi fire: Nurse's heroic efforts helped save over dozen babies
Lucknow/Jhansi (UP), Nov 17: Nurse Megha James was on duty when the fire broke out at the Jhansi hospital and she threw herself headlong into the rescue efforts, playing a hero's role by saving several babies.
Even when her salwar got burned, she refused to give up and was able to evacuate 14-15 babies with others' help.
"I had gone to take a syringe to give an injection to a child. When I came back, I saw that the (oxygen) concentrator had caught fire. I called the ward boy, who came with the fire extinguisher and tried to put it out. But by then, the fire had spread," James said.
Ten babies perished in a fire that broke out at the Neonatal Intensive Care Unit of the Maharani Laxmi Bai Medical College in Jhansi Friday night.
Faced with an enormous blaze, James's mind worked with a frenetic speed, to the extent she cared little about burning herself.
"My chappal caught fire and I burned my foot. Then my salwar caught fire. I removed my salwar and discarded it. At that time, my mind was virtually not working," she told PTI Videos.
James just wore another salwar and went back to the rescue operation.
"There was a lot of smoke, and once the lights went out, we could not see anything. The entire staff brought out at least 14-15 children. There were 11 beds in the ward with 23-24 babies," she said.
Had the lights not gone out they could have saved more children, James said. "It all happened very suddenly. None of us had expected it."
Assistant Nursing Superintendent Nalini Sood praised James's valour and recounted bits from how the rescue operation was carried out.
"The hospital staff broke the glasses of the NICU ward to evacuate the babies. It was then Nurse Megha's salwar caught fire. Instead of caring for her safety, she stayed there to rescue the babies and handed them over to people outside," she said.
Sood said James is currently undergoing treatment at the same medical college. She said she did not know the extent of her burns.
"The rescued babies were shifted to a ward very close to the NICU ward… When I recall the scene, I feel like crying," she said.
Dr Anshul Jain, the head of the anaesthesiology department at the medical college, explained the standard rescue operation and claimed the hospital followed the protocol to the T.
"In the triage process during an ICU evacuation, the policy is to evacuate less-affected patients first. The rationale behind this approach is that patients requiring minimal support can be relocated quickly, enabling a larger number of evacuations to be completed in a shorter time.
"In contrast, patients on ventilators or requiring high oxygen support demand more time and resources for evacuation," he said.
"This principle was successfully implemented in Jhansi, playing a significant role in saving many lives," Jain said.
A newborn rescued from the fire died due to illness on Sunday, Jhansi District Magistrate Avinash Kumar said.
