2nd COVID-19 vaccine trial paused over unexplained illness
New Brunswick (US): A late-stage study of Johnson & Johnson's COVID-19 vaccine candidate has been paused while the company investigates whether a study participant's unexplained illness is related to the shot.
The company said in a statement on Monday evening that illnesses, accidents and other so-called adverse events are an expected part of any clinical study, especially large studies, but that its physicians and a safety monitoring panel would try to determine what might have caused the illness.
The pause is at least the second such hold to occur among several vaccines that have reached large-scale final tests in the US.
The company declined to reveal any more details about the illness, citing the participant's privacy.
Temporary stoppages of large medical studies are relatively common. Few are made public in typical drug trials, but the work to make a coronavirus vaccine has raised the stakes on these kinds of complications.
Companies are required to investigate any serious or unexpected reaction that occurs during drug testing. Given that such tests are done on tens of thousands of people, some medical problems are a coincidence. In fact, one of the first steps the company said it will take is to determine if the person received the vaccine or a placebo.
The halt was first reported by the health news site STAT.
Final-stage testing of a vaccine made by AstraZeneca and Oxford University remains on hold in the US as officials examine whether an illness in its trial poses a safety risk. That trial was stopped when a woman developed severe neurological symptoms consistent with transverse myelitis, a rare inflammation of the spinal cord, the company has said. That company's testing has restarted elsewhere.
Johnson & Johnson was aiming to enroll 60,000 volunteers to prove if its single-dose approach is safe and protects against the coronavirus. Other vaccine candidates in the US require two shots.
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Protests in several parts of India over killing of Iran's supreme leader Ali Khamenei
Srinagar/Lucknow (PTI): From Kashmir to Karnataka, Shia mourners took to the streets in various parts of India to express outrage and grief over the death of Iranian supreme leader Ayatollah Ali Khamenei in a US-Israel strike.
Khamenei was killed in an airstrike in Tehran on Saturday during a joint Israel-US attack on Iran. Iranian state media confirmed the same on Sunday, triggering a wave of protests and mourning across the world, including India.
Kashmir — which has about 15 lakh Shias — witnessed major protests at Lal Chowk, Saida Kadal, Budgam, Bandipora, Anantnag and Pulwama, an official said.
The protesters were seen beating their chests as they shouted anti-US and anti-Israel slogans.
J&K Chief Minister Omar Abdullah expressed deep concern over the developments in Iran and appealed for calm amid widespread protests.
"Chief Minister has expressed deep concern over the unfolding developments in Iran, including reports of the killing of Iran's Supreme Leader, Ayatollah Ali Khamenei. He has appealed to all communities to remain calm, uphold peace, and avoid any actions that could lead to tension or unrest," the Office of Chief Minister said in a post on X.
Abdullah also said that his government is in close coordination with the Union Ministry of External Affairs to ensure the safety and well-being of J-K residents, including students, currently in Iran.
Expressing "profound anguish" over the assassination of Khamenei, National Conference chief Farooq Abdullah urged the administration to handle the situation with sensitivity and discretion, ensuring that those who wish to mourn are able to do so respectfully.
Mirwaiz Umar Farooq, the chief priest of Kashmir, said he was deeply saddened and outraged at Khamenei's killing.
"Deeply saddened and outraged at the brutal killing of Iran's Supreme Leader, Ayatollah Syed Ali Khamenei by the US and Israel that has shaken the Muslim world. The people of JK collectively condemn this brutality and the ongoing aggression against Iran, as well as the massacre of innocent girl students in Minab," the Mirwaiz said in a post on X.
Many Muslim bodies and organisations across the country announced a multiple-day mourning period and scheduled their protests on Monday as well in memory of the Iranian leader.
In Uttar Pradesh's capital, Lucknow, scores of people gathered near the Bara Imambara mosque and shouted slogans during the protest, with women mourners clinging to the Iranian leader's photo and weeping.
Maulana Yasoob Abbas, general secretary of All India Shia Personal Law Board, announced that effigies of US President Donald Trump and Israel's Prime Minister Benjamin Netanyahu will be burnt during the protest on Monday.
The Shia community has declared a three-day mourning, during which people will wear black, hoist black flags at their homes and organise special prayers, Abbas added.
Punjab, which has a minuscule Muslim population, saw protests and effigies being burnt in Ludhiana.
Shahi Imam Maulana Mohammad Usman Rahmani Ludhianvi, who led the protest, demanded that the central government declare a week-long national mourning.
Rehmani urged Muslims worldwide to unite against such challenges, terming Khamenei a great martyr and condemning his killing in the strongest terms.
The Shia community in Ajmer also announced a three-day mourning over the killing of Khamenei.
The announcement was made by Syed Asif Ali, a community leader, who appealed to members of the Shia community to observe mourning and refrain from celebrations during the period.
Condolence meetings were also organised at Dargah in Dorai and Taragarh in Ajmer, where members of the community offered prayers and expressed grief over the incident.
Meanwhile, several devotees from Jodhpur are stranded in Dubai after their return flights were cancelled following attacks near Dubai and Abu Dhabi.
Scenes of extreme distraught and slogannering were also witnessed in New Delhi, Bihar, Jharkhand, and Telangana, where protesters, holding Khamenei's posters, voiced their anger against the US and Israeli military actions.
However, in Karnataka’s Chikkaballapur district, where Khamenei once visited, observed silence, and shops and commercial establishments voluntarily closed.
Villagers announced a three-day mourning period as a mark of tribute to the Shia supreme leader.
All celebrations and public events have been suspended to maintain a peaceful environment in this village.
According to villagers, Ali Khamenei visited Alipura in 1986.
