COVID-19 patients can be categorised into three groups, say scientists
Washington: Scientists have identified three different types of COVID-19 disease traits in patients, depending on their comorbidities, complications, and clinical outcomes, an advance that may help target future interventions to the most risk-prone individuals.
The new study, published in the journal PLOS ONE, analysed the electronic health records (EHRs) from 14 hospitals in the midwestern US and from 60 primary care clinics in the state of Minnesota.
According to the researchers, including those from the University of Minnesota in the US, the study included 7,538 patients with confirmed COVID-19 between March 7 and August 25, 2020, of which 1,022 patients required hospitalisation.
Close to 60 per cent of the patients included in the research presented with what the researchers called "phenotype II."
They said about 23 per cent of the patients presented with "phenotype I," or the "adverse phenotype," which was associated with the worst clinical outcomes.
The researchers said these patients had the highest level of comorbidies related to heart and kidney dysfunction.
According to the study, 173 patients, or 16.9 per cent presented with "phenotype III," or the "favorable phenotype," which the scientists said was associated with the best clinical outcomes.
While this group had the lowest complication rate and mortality, the scientists said these patients had the highest rate of respiratory comorbidities as well as a 10 per cent greater risk of hospital readmission compared to the other phenotypes.
Overall, they said phenotypes I and II were associated with 7.30-fold and 2.57-fold increases in hazard of death relative to phenotype III.
Based on the results, the scientists said such phenotype-specific medical care could improve COVID-19 outcomes.
However, they believe further studies are needed to determine the utility of these findings in clinical practice.
"Patients do not suffer from COVID-19 in a uniform matter. By identifying similarly affected groups, we not only improve our understanding of the disease process, but this enables us to precisely target future interventions to the highest risk patients," the scientists added.
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Ajay Rai’s ‘nimbu-mirchi’ jibe over Rafale use in Pahalgam aftermath sparks BJP-Congress row
New Delhi: A political row erupted after Uttar Pradesh Congress president Ajay Rai used a toy plane hung with lemon and chillies to question the government’s response to the recent terror attack in Pahalgam. Rai made a symbolic reference, aimed at the Centre’s inaction despite possessing Rafale fighter jets, to the popular superstition of warding off evil with a “nimbu-mirchi” charm.
With the toy plane in his hands, Rai questioned, “When will they take action against terrorists and those who support them? Rafale jets are parked in hangars, protected with lemons and chillies. Our youth went to Pahalgam full of joy, but their bodies came back in coffins.”
The BJP responded, accusing the Congress of echoing Pakistan’s narrative. BJP’s spokesperson Shehzad Poonawala said, “Ajay Rai has not just held a toy plane, he has insulted the armed forces and played into Pakistan’s hands.” He claimed that while the Congress publicly pledged support to the Centre following the attack, its other leaders have acted to demoralize Indian forces.
Poonawala said, “This isn’t an isolated slip-up, it’s a pattern,” citing previous controversial comments by Congress leaders Siddaramaiah, Charanjit Singh Channi, Vijay Wadettiwar and RB Timmapur.
The video was picked up by Pakistan’s media, adding fuel to the BJP’s criticism that the Congress was acting like a “PR agent” for India’s adversaries. Despite the backlash, Rai stood by his statement, saying, “I am only asking when Rafale will be used. The country is waiting for action against the Pahalgam killers.” He also added that while the Congress supports the government in fighting terrorism, people have a right to question its strategy.
The Congress leadership has cautioned its members against making off-the-cuff remarks after getting caught off guard by repeated flare-ups. The Communication in-charge Jairam Ramesh clarified on X that only views expressed by Congress President Mallikarjuna Kharge, Rahul Gandhi and authorized AICC office-bearers represent the official party line.
