COVID-19 patients can be categorised into three groups, say scientists
Washington: Scientists have identified three different types of COVID-19 disease traits in patients, depending on their comorbidities, complications, and clinical outcomes, an advance that may help target future interventions to the most risk-prone individuals.
The new study, published in the journal PLOS ONE, analysed the electronic health records (EHRs) from 14 hospitals in the midwestern US and from 60 primary care clinics in the state of Minnesota.
According to the researchers, including those from the University of Minnesota in the US, the study included 7,538 patients with confirmed COVID-19 between March 7 and August 25, 2020, of which 1,022 patients required hospitalisation.
Close to 60 per cent of the patients included in the research presented with what the researchers called "phenotype II."
They said about 23 per cent of the patients presented with "phenotype I," or the "adverse phenotype," which was associated with the worst clinical outcomes.
The researchers said these patients had the highest level of comorbidies related to heart and kidney dysfunction.
According to the study, 173 patients, or 16.9 per cent presented with "phenotype III," or the "favorable phenotype," which the scientists said was associated with the best clinical outcomes.
While this group had the lowest complication rate and mortality, the scientists said these patients had the highest rate of respiratory comorbidities as well as a 10 per cent greater risk of hospital readmission compared to the other phenotypes.
Overall, they said phenotypes I and II were associated with 7.30-fold and 2.57-fold increases in hazard of death relative to phenotype III.
Based on the results, the scientists said such phenotype-specific medical care could improve COVID-19 outcomes.
However, they believe further studies are needed to determine the utility of these findings in clinical practice.
"Patients do not suffer from COVID-19 in a uniform matter. By identifying similarly affected groups, we not only improve our understanding of the disease process, but this enables us to precisely target future interventions to the highest risk patients," the scientists added.
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Main accused in Delhi Police constable murder shot dead in Sangam Vihar
New Delhi (PTI): A day after the fatal stabbing of a Delhi Police constable, the main accused in the case was shot dead in an encounter with the personnel of the force in south Delhi's Sangam Vihar area, officials said on Sunday.
Constable Kiran Pal was stabbed to death by three people on Saturday while on night patrolling duty in southeast Delhi's Govindpuri area. Two accused -- Deepak Max and Krish Gupta -- were arrested later in that day.
The third accused, Raghav -- who stabbed Pal with a knife -- was hiding in Sangam Vihar, a senior police officer of Special Cell said.
Acting on specific information, teams of NDR of Special Cell and Narcotics Cell of South East District, went to the area connecting Sangam Vihar and Surajkund Road late on Saturday night, the officer said.
The accused was identified and asked to surrender. He, however, opened fire at the police personnel who retaliated in self-defence and injured the accused.
"He was immediately taken to the ESIC Hospital, Okhla, where he died," the officer said.
A pistol with two cartridges have been seized, the police officer said, adding no police official was injured in the encounter.
Constable Kiran Pal, posted at Govindpuri Police Station, was on night patrolling duty when he stopped three people riding a scooty in the early hours of Saturday.
The accused threw stones at the constable to evade arrest but he managed to waylay them by putting his bike in front of their vehicle, the officer said.
The constable also took away the keys of the scooty and started questioning the trio during which the accused stabbed him, the officer added.
