COVID-19 patients can be categorised into three groups, say scientists
Washington: Scientists have identified three different types of COVID-19 disease traits in patients, depending on their comorbidities, complications, and clinical outcomes, an advance that may help target future interventions to the most risk-prone individuals.
The new study, published in the journal PLOS ONE, analysed the electronic health records (EHRs) from 14 hospitals in the midwestern US and from 60 primary care clinics in the state of Minnesota.
According to the researchers, including those from the University of Minnesota in the US, the study included 7,538 patients with confirmed COVID-19 between March 7 and August 25, 2020, of which 1,022 patients required hospitalisation.
Close to 60 per cent of the patients included in the research presented with what the researchers called "phenotype II."
They said about 23 per cent of the patients presented with "phenotype I," or the "adverse phenotype," which was associated with the worst clinical outcomes.
The researchers said these patients had the highest level of comorbidies related to heart and kidney dysfunction.
According to the study, 173 patients, or 16.9 per cent presented with "phenotype III," or the "favorable phenotype," which the scientists said was associated with the best clinical outcomes.
While this group had the lowest complication rate and mortality, the scientists said these patients had the highest rate of respiratory comorbidities as well as a 10 per cent greater risk of hospital readmission compared to the other phenotypes.
Overall, they said phenotypes I and II were associated with 7.30-fold and 2.57-fold increases in hazard of death relative to phenotype III.
Based on the results, the scientists said such phenotype-specific medical care could improve COVID-19 outcomes.
However, they believe further studies are needed to determine the utility of these findings in clinical practice.
"Patients do not suffer from COVID-19 in a uniform matter. By identifying similarly affected groups, we not only improve our understanding of the disease process, but this enables us to precisely target future interventions to the highest risk patients," the scientists added.
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Case registered against associate film director for sexual assault of model in Kochi
Kochi (PTI): Police on Saturday said they had registered a case against an associate director in the film industry for "sexually assaulting" a model here.
The case was registered against Jojo Kurishinkal of Chengannur in Alappuzha district at the Maradu police station on May 6.
Kurishinkal has worked in several films as an assistant and associate director.
According to the FIR, the complainant, a model based in Kochi, met Kurishinkal through a dating app in July 2023.
The FIR stated that the accused told the complainant he was a film director and had separated from his wife before proposing marriage to her.
He later allegedly assured the complainant and her mother that he would go ahead with the marriage once the legal procedures related to his divorce were completed, the FIR said.
According to the FIR, the accused later invited the complainant to his apartment in Vyttila on April 18, 2024, where he "sexually assaulted" her.
The FIR further alleged that he continued to sexually harass the woman thereafter. It also stated that the accused had "physically assaulted" the complainant on multiple occasions before later refusing to marry her.
Based on the complaint, police registered a case under Section 376(2)(n) of the Indian Penal Code for repeatedly raping the same woman.
Police said the woman’s confidential statement would be recorded, following which the accused would be summoned for questioning.
