NeoCov coronavirus found in bats may pose threat to humans in future, Chinese scientists caution
Beijing, Jan 28: A type of coronavirus, NeoCov, that spreads among bats in South Africa may pose a threat to humans in future if it mutates further, according to a study by Chinese researchers.
The yet-to-be peer-reviewed study recently posted on the preprint repository BioRxiv, shows that NeoCov is closely related to the Middle East respiratory syndrome (MERS), a viral disease first identified in Saudi Arabia in 2012.
Coronaviruses are a large family of viruses that can cause diseases ranging from the common cold to Severe Acute Respiratory Syndrome (SARS).
Researchers from Chinese Academy of Sciences and Wuhan University noted that NeoCov is found in a population of bats in South Africa and to date spreads exclusively among these animals.
In its current form, NeoCov does not infect humans but further mutations may make it potentially harmful, the researchers noted.
"In this study, we unexpectedly found that NeoCoV and its close relative, PDF-2180-CoV, can efficiently use some types of bat Angiotensin-converting enzyme 2 (ACE2) and, less favourably, human ACE2 for entry," the authors of the study noted.
ACE2 is a receptor protein on cells that provides the entry point for the coronavirus to hook into and infect a wide range of cells.
"Our study demonstrates the first case of ACE2 usage in MERS-related viruses, shedding light on a potential bio-safety threat of the human emergence of an ACE2 using "MERS-CoV-2" with both high fatality and transmission rate," they said.
The researchers further noted that infection with NeoCov could not be cross-neutralised by antibodies targeting SARS-CoV-2 or MERS-CoV.
"Considering the extensive mutations in the RBD regions of the SARS-CoV-2 variants, especially the heavily mutated Omicron variant, these viruses may hold a latent potential to infect humans through further adaptation," the authors of the study added.
A receptor-binding domain (RBD) is a key part of a virus that allows it to dock to body receptors to gain entry into cells and lead to infection.
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Will follow Shinde in any direction he goes: MLA Shirsat on allying with Pawar Sr for CM post
Mumbai, Nov 21: Shiv Sena MLA Sanjay Shirsat on Thursday said his party leaders will follow Maharashtra Chief Minister Eknath Shinde in any direction he goes post-assembly poll results and decisions taken by him will be acceptable to them.
He asserted the party will solidly back Shinde, who heads the Shiv Sena, as it trusts his leadership, comments coming two days ahead of the state assembly poll results.
Asked what if Shinde goes with rival NCP (SP) president Sharad Pawar to become the chief minister for a second time, Shirsat said, "We are committed to (follow) whatever Eknath Shinde decides. We will be solidly with him. We trust him and it will always be there."
The MLA from Chhatrapati Sambhajinagar (West) was responding to the question asked on a TV channel.
Shirsat said Shinde, who took over as CM in June 2022 after revolting against the then leadership of the Shiv Sena, only goes in the "right direction" and this has been the experience of party leaders.
Shirsat was one of the Shiv Sena MLAs who sided with Shinde at the time of the revolt.
Asked about the comments of his ally, BJP leader Pravin Darekar said, "Shirsat's remarks do not reflect the official stance of the party. Eknath Shinde's party contested against Uddhav Thackeray-led Shiv Sena (UBT) and Sharad Pawar's NCP (SP). Such an alliance with the MVA was inconceivable."
The BJP, Shinde-led Shiv Sena and NCP headed by deputy CM Ajit Pawar are members of the ruling Mahayuti alliance. On the other hand, the opposition Maha Vikas Aghadi (MVA) consists of the Congress, Shiv Sena (UBT) and NCP (Sharadchandra Pawar).
Asked what if Shinde is not made the CM again if Mahayuti retains power, Shirsat said, "A decision on this will be taken only by Eknath Shinde. It's his right and we cannot even comment on it. Whatever decision Shinde takes will be acceptable to us."
Voting for the 288-member state assembly concluded on November 20 and results will be declared on November 23.
