NeoCov coronavirus found in bats may pose threat to humans in future, Chinese scientists caution
Beijing, Jan 28: A type of coronavirus, NeoCov, that spreads among bats in South Africa may pose a threat to humans in future if it mutates further, according to a study by Chinese researchers.
The yet-to-be peer-reviewed study recently posted on the preprint repository BioRxiv, shows that NeoCov is closely related to the Middle East respiratory syndrome (MERS), a viral disease first identified in Saudi Arabia in 2012.
Coronaviruses are a large family of viruses that can cause diseases ranging from the common cold to Severe Acute Respiratory Syndrome (SARS).
Researchers from Chinese Academy of Sciences and Wuhan University noted that NeoCov is found in a population of bats in South Africa and to date spreads exclusively among these animals.
In its current form, NeoCov does not infect humans but further mutations may make it potentially harmful, the researchers noted.
"In this study, we unexpectedly found that NeoCoV and its close relative, PDF-2180-CoV, can efficiently use some types of bat Angiotensin-converting enzyme 2 (ACE2) and, less favourably, human ACE2 for entry," the authors of the study noted.
ACE2 is a receptor protein on cells that provides the entry point for the coronavirus to hook into and infect a wide range of cells.
"Our study demonstrates the first case of ACE2 usage in MERS-related viruses, shedding light on a potential bio-safety threat of the human emergence of an ACE2 using "MERS-CoV-2" with both high fatality and transmission rate," they said.
The researchers further noted that infection with NeoCov could not be cross-neutralised by antibodies targeting SARS-CoV-2 or MERS-CoV.
"Considering the extensive mutations in the RBD regions of the SARS-CoV-2 variants, especially the heavily mutated Omicron variant, these viruses may hold a latent potential to infect humans through further adaptation," the authors of the study added.
A receptor-binding domain (RBD) is a key part of a virus that allows it to dock to body receptors to gain entry into cells and lead to infection.
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Operation Sindoor: India carries out military strikes on nine terror targets in Pakistan, PoK
New Delhi (PTI): Retaliating against the Pahalgam terror attack two weeks ago, Indian armed forces on early Wednesday carried out missile strikes on nine terror targets in Pakistan and Pakistan-Occupied Kashmir, including in Bahawalpur, a stronghold of the banned Jaish-e-Mohammed.
The military strikes were carried out under Operation Sindoor, the defence ministry said in a statement at 1.44 am. It said the actions by the Indian armed forces were "focused, measured and non-escalatory in nature".
Pakistan Prime Minister Shehbaz Sharif termed the Indian missile strikes an "act of war" and said his country has every right to give a "befitting reply".
The Indian statement said, "A little while ago, the Indian Armed forces launched 'Operation Sindoor' hitting terrorist infrastructure in Pakistan and Pakistan-occupied Jammu and Kashmir from where terrorist attacks against India have been planned and directed."
"No Pakistani military facilities have been targeted. India has demonstrated considerable restraint in selection of targets and method of execution," it said.
Sources added that the strikes on all nine targets were successful and Prime Minister Narendra Modi was monitoring Operation Sindoor closely.
Among the nine sites targeted are the JeM headquarters in Bahawalpur and the Lashkar-e-Taiba's in Muridke, both in Pakistan Punjab, officials said.
India's actions come two weeks after the April 22 Pahalgam terror attack that triggered widespread outrage in India and abroad.
"These steps come in the wake of the barbaric Pahalgam terrorist attack in which 25 Indians and one Nepali citizen were murdered," the defence ministry statement said.
"We are living up to the commitment that those responsible for this attack will be held accountable," it said.
In a post on 'X' in Hindi shortly after the strikes, Defence Minister Rajnath Singh said, "Long live Mother India!" (Bharat Mata Ki Jai)".
"Justice is Served," the Indian Army said in its post.
Pakistan Army spokesperson Lt Gen Ahmed Sharif Chaudhry said missile strikes were fired by India at Kotli and Muzaffarabad in Pakistan-occupied Kashmir and Bahawalpur.
Some time ago, India launched air strikes in in Bahwalpur's Ahmed East area, Kotli and Muzaffarabad at three places from the air, he told ARY News channel.
"All of our air force jets are airborne. This cowardly and shameful attack was carried out from within India's airspace. They were never allowed to come and intrude into the space of Pakistan," he said.
"Let me say it unequivocally: Pakistan will respond to this at a time and place of its own choosing. This heinous provocation will not go unanswered," he added.
Sources in the Indian military establishment said all air defence units have been put on alert along the frontier with Pakistan.
Following the operation, India reached out to several leading countries, including the US, Russia, the UK, UAE and Saudi Arabia and briefed them about the military strike on the nine terror targets in Pakistan and Pakistan-Occupied-Kashmir, the sources said.
"Senior Indian officials have spoken to their counterparts in a number of countries to brief them on the steps taken by India," said a source.
The operation came days after Modi gave the armed forces full freedom to respond to the Pahalgam terror attack.
In a high-level meeting with the top defence brass, the prime minister on April 29 gave the armed forces "complete operational freedom" to decide on the mode, targets and timing of the response to the Pahalgam terror attack.
Modi also emphasised the national resolve to deal a "crushing blow to terrorism".
Union Minister Kiren Rijiju tweets, "#OperationSindoor"
— ANI (@ANI) May 6, 2025
(Video Source: Kiren Rijiju/X) pic.twitter.com/kdBY2xeHqN
#WATCH | Visuals from an undisclosed location in J&K as the Indian Armed Forces launched ‘Operation Sindoor’, hitting terrorist infrastructure in Pakistan and Pakistan-occupied Jammu and Kashmir from where terrorist attacks against India have been planned and directed.… pic.twitter.com/3D20pDXkND
— ANI (@ANI) May 6, 2025
