New therapy could help combat drug addiction
New York, July 1: Researchers have developed a treatment that may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.
When tested on rats, the new treatment was effective in reducing the animals' cravings, according to the findings published in the Journal of Medicinal Chemistry.
When someone habitually misuses drugs, their brain chemistry is changed in ways that make it harder for them to quit taking drugs despite negative consequences.
Once someone has developed this brain disorder, their mind pays sharper attention to cues that encourage drug use, making it harder for them to abstain.
Serotonin, a brain chemical that transmits information between neural regions, is a key player in these changes.
The researchers found that the serotonin 2C receptors in drug addicts do not work as well as they should.
The team led by researchers from the University of Texas Medical Branch at Galveston in the US designed, synthesised and pharmacologically evaluated a series of small molecule therapeutics designed to restore the weakened signalling.
The findings showed that the novel therapeutic may help reverse chemical imbalances made to the brain by habitual drug use.
In their experiment, the researchers trained rats to press on a lever for cocaine infusions at certain light cues.
Once the rats learned this cocaine-seeking behaviour, half of them received the most promising therapeutic and the other half received only saline.
The findings showed that the animals treated with the new therapeutic pressed the lever for cocaine far fewer times than the saline-treated control animals, even when reinforced with the cocaine-associated light cues.
"We are the first to show that a serotonin 2C receptor therapeutic of this type can be successfully used to decrease drug-seeking behaviours," said Kathryn Cunningham, Director of Center for Addiction Research at the University of Texas Medical Branch at Galveston.
"Our findings are especially exciting because in addition to someday helping people to recover from drug addiction, impaired functioning of the serotonin 2C receptor is also thought to contribute to other chronic health issues such as depression, impulsivity disorders, obesity and schizophrenia," Cunningham added.
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Four held in Kalaburagi for brutal murder of man
Kalaburagi: Four men have been arrested in Kalaburagi on charge of hacking a man with lethal weapons and pelting stones at him under the limits of Station Bazaar Police Station recently.
According to police sources, Anand Jalak Shinde (34), Ashitosh Jalak Shinde (30), Imran Mehboob Sheikh (28) and Sohaib Anwar Qureshi have been arrested. The men are accused of the brutal murder of Syed Mehboob, a resident of Station Bazaar Upper Line Hamalawadi in the city.
An FIR was filed by the Station Bazaar Police Station based on a complaint given by Syed Ismail, father of the deceased Syed Mehboob.
Following quick probe, the police team successfully arrested the suspects within 24 hours. The arrested men were produced in court and have been sent to judicial custody.
The City Police Commissionerate has appreciated in an official release the police team’s quick solving of the murder case and arrest of the four men accused of murdering Syed Mehboob.
