New therapy could help combat drug addiction
New York, July 1: Researchers have developed a treatment that may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.
When tested on rats, the new treatment was effective in reducing the animals' cravings, according to the findings published in the Journal of Medicinal Chemistry.
When someone habitually misuses drugs, their brain chemistry is changed in ways that make it harder for them to quit taking drugs despite negative consequences.
Once someone has developed this brain disorder, their mind pays sharper attention to cues that encourage drug use, making it harder for them to abstain.
Serotonin, a brain chemical that transmits information between neural regions, is a key player in these changes.
The researchers found that the serotonin 2C receptors in drug addicts do not work as well as they should.
The team led by researchers from the University of Texas Medical Branch at Galveston in the US designed, synthesised and pharmacologically evaluated a series of small molecule therapeutics designed to restore the weakened signalling.
The findings showed that the novel therapeutic may help reverse chemical imbalances made to the brain by habitual drug use.
In their experiment, the researchers trained rats to press on a lever for cocaine infusions at certain light cues.
Once the rats learned this cocaine-seeking behaviour, half of them received the most promising therapeutic and the other half received only saline.
The findings showed that the animals treated with the new therapeutic pressed the lever for cocaine far fewer times than the saline-treated control animals, even when reinforced with the cocaine-associated light cues.
"We are the first to show that a serotonin 2C receptor therapeutic of this type can be successfully used to decrease drug-seeking behaviours," said Kathryn Cunningham, Director of Center for Addiction Research at the University of Texas Medical Branch at Galveston.
"Our findings are especially exciting because in addition to someday helping people to recover from drug addiction, impaired functioning of the serotonin 2C receptor is also thought to contribute to other chronic health issues such as depression, impulsivity disorders, obesity and schizophrenia," Cunningham added.
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KSRTC introduces gender ticketing in buses across Kerala
Thiruvananthapuram (PTI): The KSRCTC on Saturday began implementing gender ticketing in buses operating across the state.
According to a Kerala State Road Transport Corporation (KSRTC) circular issued on Friday, the gender ticketing system is intended to record whether a passenger is a woman, a man or a child in tickets issued on KSRTC buses from Saturday.
To facilitate the system, Electronic Ticketing Machines (ETMs) have been updated.
The circular stated that conductors in all KSRTC depots should record the gender category of passengers while issuing tickets through the ETMs.
Options for women, men, and children have been included in the ETMs to identify passenger categories when issuing tickets.
The printed tickets generated by the ETMs will also indicate the passenger's category, officials said.
The UDF had promised free KSRTC travel for women across the state during the Assembly election campaign.
UDF, which won 102 of 140 seats, would soon form the government after the Congress party finalises the discussion on the next Chief Minister.
The introduction of gender ticketing is being viewed as an effort to estimate the number of women travelling daily on KSRTC buses before implementing the poll promise.
Some conductors have reportedly raised concerns over the additional time required to record passenger details, especially during rush hours.
