New therapy could help combat drug addiction
New York, July 1: Researchers have developed a treatment that may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.
When tested on rats, the new treatment was effective in reducing the animals' cravings, according to the findings published in the Journal of Medicinal Chemistry.
When someone habitually misuses drugs, their brain chemistry is changed in ways that make it harder for them to quit taking drugs despite negative consequences.
Once someone has developed this brain disorder, their mind pays sharper attention to cues that encourage drug use, making it harder for them to abstain.
Serotonin, a brain chemical that transmits information between neural regions, is a key player in these changes.
The researchers found that the serotonin 2C receptors in drug addicts do not work as well as they should.
The team led by researchers from the University of Texas Medical Branch at Galveston in the US designed, synthesised and pharmacologically evaluated a series of small molecule therapeutics designed to restore the weakened signalling.
The findings showed that the novel therapeutic may help reverse chemical imbalances made to the brain by habitual drug use.
In their experiment, the researchers trained rats to press on a lever for cocaine infusions at certain light cues.
Once the rats learned this cocaine-seeking behaviour, half of them received the most promising therapeutic and the other half received only saline.
The findings showed that the animals treated with the new therapeutic pressed the lever for cocaine far fewer times than the saline-treated control animals, even when reinforced with the cocaine-associated light cues.
"We are the first to show that a serotonin 2C receptor therapeutic of this type can be successfully used to decrease drug-seeking behaviours," said Kathryn Cunningham, Director of Center for Addiction Research at the University of Texas Medical Branch at Galveston.
"Our findings are especially exciting because in addition to someday helping people to recover from drug addiction, impaired functioning of the serotonin 2C receptor is also thought to contribute to other chronic health issues such as depression, impulsivity disorders, obesity and schizophrenia," Cunningham added.
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Hemant Karkare killed by RSS-linked cop, not Kasab: Maharashtra LoP Vijay Wadettiwar
BJP writes to ECI for action against Cong leader Wadettiwar for 'defaming' Ujjwal Nikam
Mumbai, May 5: The BJP has written to the Election Commission of India seeking action against Congress and the opposition leader, Vijay Wadettiwar, for allegedly peddling lies and defaming its Mumbai North Central nominee and ex-26/11 prosecution lawyer Ujjwal Nikam.
Wadettiwar, the leader of the opposition in the Maharashtra legislative assembly, purportedly called Nikam an "anti-national" and accused him of hiding the information that then Maharashtra ATS chief Hemant Karkare wasn't killed by Kasab's bullet during the 26/11 terror attack, but fell to a bullet of a policeman affiliated to RSS.
His allegations were based on the book "Who Killed Karkare" written by retired police officer SM Mushriff.
"As a responsible leader, the opposition leader should desist from making such comments that can help the enemy nation," Nikam said.
Terming Wadettiwar's statements as "false and not based on facts", Mumbai BJP president Ashish Shekar claimed they were aimed at defaming Ujjwal Nikam and inciting emotions.
"We have written to the Election Commission of India seeking action against Wadettiwar who is a star campaigner (of Congress) and also against the Congress party for peddling lies," he added.
Shelar further said (Ajmal) Kasab was sentenced to death for killing innocent people after following a due process of law.
Kasab was the lone terrorist who was captured alive by Mumbai Police during the 26/11 terror attack by Pakistani terrorists in which at least 166 people were killed and several others were injured.
Shelar wondered whether Shiv Sena (UBT) chief Uddhav Thackeray supported the statement made by the Congress leader.
A former special public prosecutor, Nikam had represented the state in high-profile cases like the Mumbai serial bomb blasts and the 2008 Mumbai terror attack.
He is making his political foray from Mumbai North Central seat on a BJP ticket and is pitted against city Congress chief Varsha Gaikwad.
