New therapy could help combat drug addiction
New York, July 1: Researchers have developed a treatment that may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.
When tested on rats, the new treatment was effective in reducing the animals' cravings, according to the findings published in the Journal of Medicinal Chemistry.
When someone habitually misuses drugs, their brain chemistry is changed in ways that make it harder for them to quit taking drugs despite negative consequences.
Once someone has developed this brain disorder, their mind pays sharper attention to cues that encourage drug use, making it harder for them to abstain.
Serotonin, a brain chemical that transmits information between neural regions, is a key player in these changes.
The researchers found that the serotonin 2C receptors in drug addicts do not work as well as they should.
The team led by researchers from the University of Texas Medical Branch at Galveston in the US designed, synthesised and pharmacologically evaluated a series of small molecule therapeutics designed to restore the weakened signalling.
The findings showed that the novel therapeutic may help reverse chemical imbalances made to the brain by habitual drug use.
In their experiment, the researchers trained rats to press on a lever for cocaine infusions at certain light cues.
Once the rats learned this cocaine-seeking behaviour, half of them received the most promising therapeutic and the other half received only saline.
The findings showed that the animals treated with the new therapeutic pressed the lever for cocaine far fewer times than the saline-treated control animals, even when reinforced with the cocaine-associated light cues.
"We are the first to show that a serotonin 2C receptor therapeutic of this type can be successfully used to decrease drug-seeking behaviours," said Kathryn Cunningham, Director of Center for Addiction Research at the University of Texas Medical Branch at Galveston.
"Our findings are especially exciting because in addition to someday helping people to recover from drug addiction, impaired functioning of the serotonin 2C receptor is also thought to contribute to other chronic health issues such as depression, impulsivity disorders, obesity and schizophrenia," Cunningham added.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
Regulator DGCA eases flight duty norms for pilots amid IndiGo crisis
Mumbai (PTI): Aviation watchdog DGCA on Friday eased the flight duty norms by allowing substitution of leaves with a weekly rest period amid massive operational disruptions at IndiGo, according to sources.
As per the revised Flight Duty Time Limitations (FDTL) norms, "no leave shall be substituted for weekly rest", which means that weekly rest period and leaves are to be treated separately. The clause was part of efforts to address fatigue issues among the pilots.
Citing IndiGo flight disruptions, sources told PTI that the Directorate General of Civil Aviation (DGCA) has decided to withdraw the provision 'no leave shall be substituted for weekly rest' from the FDTL norms.
ALSO READ: 49 Indigo flights likely to be cancelled from Hyderabad
"In view of the ongoing operational disruptions and representations received from various airlines regarding the need to ensure continuity and stability of operations, it has been considered necessary to review the said provision," DGCA said in a communication dated December 5.
The gaps in planning ahead of the implementation of the revised FDTL, the second phase of which came into force from November 1, have resulted in crew shortage at IndiGo and is one of the key reasons for the current disruptions.
#BREAKING: #DGCA relaxes a clause which debarred airlines to club leaves with weekly rest to mitigate #IndiGo crisis
— Economic Times (@EconomicTimes) December 5, 2025
🔴 Catch the day's latest news here ➠ https://t.co/8eVBGnsJUA 🗞️ pic.twitter.com/KUWc8R2Kso
