WHO issues global alert on rare vision loss linked to popular diabetes, weight loss drugs
Geneva: The World Health Organization (WHO) has issued a global safety alert warning of a rare but potentially irreversible vision condition associated with popular diabetes and weight-loss drugs containing semaglutide, including Ozempic, Rybelsus, and Wegovy.
The alert, released on 27 June, highlights the risk of non-arteritic anterior ischaemic optic neuropathy (NAION), a condition that can lead to sudden, painless, and irreversible loss of vision, typically in one eye.
“There is currently no effective treatment available for NAION, and the vision loss is generally irreversible,” the WHO stated in its warning.
The European Medicines Agency (EMA) has already acted on this risk by updating the safety profiles of these drugs. Following a comprehensive safety review, the agency’s Pharmacovigilance Risk Assessment Committee (PRAC) recommended that NAION be listed as a “very rare” side effect, potentially affecting up to 1 in 10,000 users.
Semaglutide, a GLP-1 receptor agonist, has seen widespread use globally for treating type 2 diabetes and obesity. However, the growing popularity of these drugs has also brought new safety concerns to light.
NAION is considered the second most common optic neuropathy after glaucoma and can present without pain, making early detection more challenging. Common symptoms include sudden vision loss and optic disc swelling.
The WHO noted that its global adverse event database, VigiBase, had received several individual case safety reports of NAION linked to semaglutide use from multiple countries. After assessing these reports during its May 2025 meeting, the WHO Advisory Committee on Safety of Medicinal Products (ACSoMP) recommended revising semaglutide’s risk management plans.
Healthcare professionals worldwide are now being urged to inform patients about this potential risk and to remain vigilant. Patients currently using semaglutide or considering it are advised to seek immediate medical help if they experience any sudden changes in vision.
The alert is part of continued pharmacovigilance efforts around GLP-1-based medications, which have transformed diabetes and obesity care but continue to face evolving scrutiny as their use expands.
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Karnataka: Home Department asks motorists to drive on highways with caution to avoid robbery
Belagavi: The Home Department has advised motorists to stay alert while travelling on national and state highways, warning that gangs involved in robbery and extortion have been active in several stretches. It said people should be extra cautious if anyone tries to stop their vehicle in isolated areas.
Replying to an unstarred question on Thursday, the department said Karnataka has recorded 403 highway robbery cases in the past three years. According to the data, national highways saw 81 extortion and 23 robbery cases in 2023, followed by 66 extortion and 16 robbery cases in 2024. Until November 15 this year, 51 extortion and 14 robbery cases have been reported.
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On state highways, 39 extortion and 17 robberies were reported in 2023, while 2024 saw 35 extortion and 22 robbery cases. In 2025 so far, 20 extortion and 19 robbery cases have taken place. The department noted that curbing highway robberies remains a major challenge for the police.
To tackle the issue, police stations have been directed to set up regular checkpoints on stretches of highways passing through their limits. Suspicious individuals and vehicles are being checked. Two-wheelers have been allocated to every station for night patrol, and staff have been instructed to conduct night rounds using vehicles fitted with sirens and red lights.
